发明申请
- 专利标题： Pharmaceutically active aromatic guanylhydrazones
- 专利标题（中）： 药用活性芳香脒腙
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申请号： US11052325申请日： 2005-02-07
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公开(公告)号： US20050171176A1公开(公告)日： 2005-08-04
- 发明人: Dorian Bevec , Joachim Hauber , Sabine Obert , Gyorgy Keri , Laszlo Orfi , Istvan Szekely , Axel Choidas , Gerald Bacher
- 申请人： Dorian Bevec , Joachim Hauber , Sabine Obert , Gyorgy Keri , Laszlo Orfi , Istvan Szekely , Axel Choidas , Gerald Bacher
- 优先权： EP00102050.2 20000202
- 主分类号： A61K31/155
- IPC分类号： A61K31/155 ; A61K31/17 ; A61K31/22 ; A61K31/4164 ; A61K45/06 ; A61P31/04 ; A61P31/18 ; C07C281/18 ; A61K31/4172 ; A61K31/165
摘要：
The present invention relates to aromatic guanylhydrazone compounds and their use as pharmaceutically active agents, especially for prophylaxis and treatment of virally caused diseases and infections, including opportunistic infections. The inventive guanylhydrazone compounds are also useful as inhibitors of deoxyhypusine synthase and as inhibitors for nuclear export in infectious diseases and may be used to regulate bacterially induced TNF-α production. Furthermore, the aromatic guanylhydrazones exhibit antibacterial activity against Gram positive and Gram negative bacteria and can be regarded as a novel class of antibiotics. In addition, methods for prophylaxis and treatment of virally or bacterially induced infections and diseases are disclosed together with pharmaceutical compositions useful within said methods containing at least one aromatic guanylhydrazone of the present invention as active ingredient.