公开(公告)号：US20050171176A1

公开(公告)日：2005-08-04

申请号：US11052325

申请日：2005-02-07

申请人： Dorian Bevec ,  Joachim Hauber ,  Sabine Obert ,  Gyorgy Keri ,  Laszlo Orfi ,  Istvan Szekely ,  Axel Choidas ,  Gerald Bacher

发明人： Dorian Bevec ,  Joachim Hauber ,  Sabine Obert ,  Gyorgy Keri ,  Laszlo Orfi ,  Istvan Szekely ,  Axel Choidas ,  Gerald Bacher

IPC分类号： A61K31/155 ,  A61K31/17 ,  A61K31/22 ,  A61K31/4164 ,  A61K45/06 ,  A61P31/04 ,  A61P31/18 ,  C07C281/18 ,  A61K31/4172 ,  A61K31/165

CPC分类号： A61K45/06 ,  A61K31/155 ,  A61K31/17 ,  A61K31/4164 ,  C07C281/18 ,  Y02A50/402 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/479 ,  Y02A50/481

摘要： The present invention relates to aromatic guanylhydrazone compounds and their use as pharmaceutically active agents, especially for prophylaxis and treatment of virally caused diseases and infections, including opportunistic infections. The inventive guanylhydrazone compounds are also useful as inhibitors of deoxyhypusine synthase and as inhibitors for nuclear export in infectious diseases and may be used to regulate bacterially induced TNF-α production. Furthermore, the aromatic guanylhydrazones exhibit antibacterial activity against Gram positive and Gram negative bacteria and can be regarded as a novel class of antibiotics. In addition, methods for prophylaxis and treatment of virally or bacterially induced infections and diseases are disclosed together with pharmaceutical compositions useful within said methods containing at least one aromatic guanylhydrazone of the present invention as active ingredient.

摘要翻译： 本发明涉及芳香脒腙化合物及其作为药物活性剂的用途，特别是用于预防和治疗病毒引起的疾病和感染，包括机会性感染。 本发明的脒腙化合物也可用作脱氧酪氨酸合成酶的抑制剂，并且可用作感染性疾病中核出口的抑制剂，并可用于调节细菌诱导的TNF-α产生。 此外，芳香脒腙对革兰氏阳性和革兰氏阴性细菌具有抗菌活性，可被认为是一类新型抗生素。 此外，还公开了用于预防和治疗病毒或细菌诱导的感染和疾病的方法以及在含有本发明的至少一种芳香脒腙作为活性成分的所述方法中有用的药物组合物。

公开(公告)号：US20090215699A1

公开(公告)日：2009-08-27

申请号：US11722865

申请日：2006-01-05

申请人： Gerald Bacher ,  Karl Heinrich Wiesmüller ,  Birgit Schäfer ,  Joachim Hauber

发明人： Gerald Bacher ,  Karl Heinrich Wiesmüller ,  Birgit Schäfer ,  Joachim Hauber

IPC分类号： A61K38/10 ,  C07K7/00

CPC分类号： A61K38/08

摘要： The inventive peptides were found to have strong antiviral activity against HIV in general and particularly strong drug-resistant HIV activity without exerting any toxic or antiproliferative effects on cells. Consequently, using of the inventive peptides improves the conventional HIV therapy with its toxic side effects.

摘要翻译： 发现本发明的肽通常具有抗艾滋病病毒的强抗病毒活性，特别是强耐药性的HIV活性，而对细胞没有任何毒性或抗增殖作用。 因此，使用本发明的肽改善了其毒性副作用的常规HIV治疗。

公开(公告)号：US08871516B2

公开(公告)日：2014-10-28

申请号：US12522127

申请日：2008-01-03

申请人： Joachim Hauber ,  Frank Buchholz ,  Ilona Hauber ,  Francis A Stewart ,  Indrani Sarkar

发明人： Joachim Hauber ,  Frank Buchholz ,  Ilona Hauber ,  Francis A Stewart ,  Indrani Sarkar

IPC分类号： C12N15/87 ,  C12N15/10 ,  C12N15/86 ,  C12N15/00 ,  C12N9/90 ,  C12N9/00 ,  C07H21/02 ,  C07H21/04 ,  C12P21/04 ,  C12P21/06

CPC分类号： C12N15/86 ,  C12N15/1058 ,  C12N2740/16043 ,  C12N2800/30

摘要： The present invention is directed to a method for preparing an expression vector encoding a tailored recombinase, wherein said tailored recombinase recombines asymmetric target sites within the LTR of proviral DNA of a retrovirus inserted into the genome of a host cell and is useful as means for excising the provirus from the genome of the host cell. The present invention further relates to an in vitro-method of optimising the treatment of a retroviral infection of a subject and to the use of tailored recombinases for the preparation of pharmaceutical compositions for reducing the viral load in a subjected infected by a retrovirus.

摘要翻译： 本发明涉及一种编码编码修饰重组酶的表达载体的方法，其中所述修整的重组酶重组插入到宿主细胞基因组中的逆转录病毒DNA的前病毒DNA的LTR内的不对称靶位点，并且可用作切除的手段 来自宿主细胞基因组的原病毒。 本发明还涉及优化对受试者的逆转录病毒感染的治疗的体外方法，以及使用调整的重组酶来制备用于减少由逆转录病毒感染的病毒的病毒载量的药物组合物。

公开(公告)号：US06339150B1

公开(公告)日：2002-01-15

申请号：US09137784

申请日：1998-08-21

申请人： Helmut Bachmayer ,  Ernst Boehnlein ,  Warner C. Greene ,  Joachim Hauber

发明人： Helmut Bachmayer ,  Ernst Boehnlein ,  Warner C. Greene ,  Joachim Hauber

IPC分类号： C07H2104

CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K16/1036 ,  C12N2740/10022 ,  C12N2740/10043 ,  C12N2740/14022 ,  C12N2740/14043 ,  C12N2740/16322 ,  G03C7/3013 ,  G03C7/36

摘要： Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II and, in some cases, both the Rev and the Rex function and are, therefore, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example protect cells against the deleterious effects of viral, e.g. HIV-1, infection.

摘要翻译： 衍生自HIV-1的rev基因产物或HTLV-1的rex基因产物和相应的突变基因的具有抑制HIV-1中Rev功能和/或Rex功能的能力的病毒基因表型表达的显性阻遏物 HTLV-I和HTLV-II，在某些情况下，均为Rev和Rex功能，因此在多种病毒物种中活跃。 这样的显性病毒突变体可用作抗病毒剂，例如保护细胞免受病毒的有害影响，例如， HIV-1，感染。

公开(公告)号：US06287809B1

公开(公告)日：2001-09-11

申请号：US09224247

申请日：1998-12-30

申请人： Helmut Bachmayer ,  Ernst Boehnlein ,  Warner C. Greene ,  Joachim Hauber

发明人： Helmut Bachmayer ,  Ernst Boehnlein ,  Warner C. Greene ,  Joachim Hauber

IPC分类号： C12P2106

CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K16/1036 ,  C12N2740/10022 ,  C12N2740/10043 ,  C12N2740/14022 ,  C12N2740/14043 ,  C12N2740/16322 ,  G03C7/3013 ,  G03C7/36

摘要： Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II and, in some cases, both the Rev and the Rex function and are, therefore, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example protect cells against the deleterious effects of viral, e.g. HIV-1, infection.

摘要翻译： 衍生自HIV-1的rev基因产物或HTLV-1的rex基因产物和相应的突变基因的具有抑制HIV-1中Rev功能和/或Rex功能的能力的病毒基因表型表达的显性阻遏物 HTLV-I和HTLV-II，在某些情况下，均为Rev和Rex功能，因此在多种病毒物种中活跃。 这样的显性病毒突变体可用作抗病毒剂，例如保护细胞免受病毒的有害影响，例如， HIV-1，感染。

公开(公告)号：US20130164271A1

公开(公告)日：2013-06-27

申请号：US13698410

申请日：2011-05-27

申请人： Joachim Hauber ,  Jan Chemnitz ,  Frank Buchholz ,  Janet Chusainow

发明人： Joachim Hauber ,  Jan Chemnitz ,  Frank Buchholz ,  Janet Chusainow

IPC分类号： C12N9/12 ,  C12N15/10

CPC分类号： C12N9/1241 ,  C12N9/22 ,  C12N15/1058 ,  C12N2740/16022

摘要： The present invention relates to a method for preparing an expression vector encoding a tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences within the long terminal repeat (LTR) of proviral DNA of a plurality of retrovirus strains inserted into the genome of a host cell, as well as to the obtained expression vector, cells transfected with this, expressed recombinase and pharmaceutical compositions comprising the expression vector, cells and/or recombinase. Pharmaceutical compositions are useful, e.g., in treatment and/or prevention of retrovirus infection. In particular, asymmetric target sequences present in a plurality of HIV strains are disclosed, as well as tailored recombinases capable of combining these sequences (Tre 3.0 and 4.0) and expression vectors encoding them.

公开(公告)号：US20100172881A1

公开(公告)日：2010-07-08

申请号：US12522127

申请日：2008-01-03

申请人： Joachim Hauber ,  Frank Buchholz ,  Ilona Hauber ,  Francis A. Stewart ,  Indrani Sarkar

发明人： Joachim Hauber ,  Frank Buchholz ,  Ilona Hauber ,  Francis A. Stewart ,  Indrani Sarkar

IPC分类号： A61K35/12 ,  C40B50/06 ,  C12N15/74 ,  C07H21/00 ,  C12N9/90 ,  C12N5/074 ,  A61K31/7088 ,  A61K38/52 ,  C12Q1/68 ,  A61P31/12

CPC分类号： C12N15/86 ,  C12N15/1058 ,  C12N2740/16043 ,  C12N2800/30

摘要： The present invention is directed to a method for preparing an expression vector encoding a tailored recombinase, wherein said tailored recombinase recombines asymmetric target sites within the LTR of proviral DNA of a retrovirus inserted into the genome of a host cell and is useful as means for excising the provirus from the genome of the host cell. The present invention further relates to an in vitro-method of optimising the treatment of a retroviral infection of a subject and to the use of tailored recombinases for the preparation of pharmaceutical compositions for reducing the viral load in a subjected infected by a retrovirus.

摘要翻译： 本发明涉及一种编码编码修饰重组酶的表达载体的方法，其中所述修整的重组酶重组插入到宿主细胞基因组中的逆转录病毒DNA的前病毒DNA的LTR内的不对称靶位点，并且可用作切除的手段 来自宿主细胞基因组的原病毒。 本发明还涉及优化对受试者的逆转录病毒感染的治疗的体外方法，以及使用调整的重组酶来制备用于减少由逆转录病毒感染的病毒的病毒载量的药物组合物。