发明申请
- 专利标题: Coated fine particles containing drug for intrabuccally fast disintegrating tablet
- 专利标题(中): 含有药物的包衣微粒含有快速崩解片剂
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申请号: US10975210申请日: 2004-10-27
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公开(公告)号: US20050175689A1公开(公告)日: 2005-08-11
- 发明人: Ippei Kurimoto , Yuki Kasashima , Hitoshi Kawai , Yuuki Takaishi , Masataka Katsuma , Hiroshi Ohi , Takayuki Yoshida , Hiroaki Tasaki
- 申请人: Ippei Kurimoto , Yuki Kasashima , Hitoshi Kawai , Yuuki Takaishi , Masataka Katsuma , Hiroshi Ohi , Takayuki Yoshida , Hiroaki Tasaki
- 申请人地址: JP Chuo-ku 103-8411
- 专利权人: Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人: Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Chuo-ku 103-8411
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61K9/20
摘要:
The present invention makes it possible to provide drug-containing coated microparticles for quick-disintegrating oral tablets wherein microparticles containing a drug with an unpleasant taste are coated with a film composed of (1) a pH-independent water-insoluble polymer accounting for 60% or more but less than 80% of the film and (2) a pH-independent water-soluble substance accounting for more than 20% to 40% or less of the film, these microparticles being characterized in that the rate of dissolution of the drug from the drug-containing microparticles is 0% to 10% in one minute and 80% to 100% in 30 minutes, and the average particle diameter is 350 μm or less, in order to realize sufficient control of oral drug dissolution and fast gastrointestinal drug dissolution.
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