公开(公告)号：US07815939B2

公开(公告)日：2010-10-19

申请号：US11458582

申请日：2006-07-19

申请人： Yuki Kasashima ,  Ippei Kurimoto ,  Hitoshi Kawai

发明人： Yuki Kasashima ,  Ippei Kurimoto ,  Hitoshi Kawai

IPC分类号： A61K9/24 ,  A61K9/16

CPC分类号： A61K9/5078 ,  A61K9/5047

摘要： Regarding an object of sufficient suppression of unpleasant taste in the oral cavity and quick dissolution in the gastrointestinal tract, which is generated when a drug having a strong unpleasant taste such as bitterness, astringency and the like is applied to a quickly disintegrating preparations in the oral cavity, this invention has achieved the aforementioned object for the first time by employing a constitution of coating a coat of a water-soluble polymer and a specified ratio of a pH-independent water-insoluble polymer and hydroxypropylcellulose.

摘要翻译： 关于在口腔中充分抑制不愉快味道和快速溶解在胃肠道中的目的，当将具有强烈令人不快的味道（例如苦味，涩味等）的药物施用于口服的快速崩解制剂时产生 本发明通过使用涂布水溶性聚合物的涂层和与pH无关的水不溶性聚合物和羟丙基纤维素的规定比例的结构第一次实现了上述目的。

公开(公告)号：US20070231399A1

公开(公告)日：2007-10-04

申请号：US11458582

申请日：2006-07-19

申请人： Yuki Kasashima ,  Ippei Kurimoto ,  Hitoshi Kawai

发明人： Yuki Kasashima ,  Ippei Kurimoto ,  Hitoshi Kawai

IPC分类号： A61K9/52

CPC分类号： A61K9/5078 ,  A61K9/5047

摘要： Regarding an object of sufficient suppression of unpleasant taste in the oral cavity and quick dissolution in the gastrointestinal tract, which is generated when a drug having a strong unpleasant taste such as bitterness, astringency and the like is applied to a quickly disintegrating preparations in the oral cavity, this invention has achieved the aforementioned object for the first time by employing a constitution of coating a coat of a water-soluble polymer and a specified ratio of a pH-independent water-insoluble polymer and hydroxypropylcellulose.

摘要翻译： 关于在口腔中充分抑制不愉快味道和快速溶解在胃肠道中的目的，当将具有强烈令人不快的味道（例如苦味，涩味等）的药物施用于口服的快速崩解制剂时产生 本发明通过使用涂布水溶性聚合物的涂层和与pH无关的水不溶性聚合物和羟丙基纤维素的规定比例的结构第一次实现了上述目的。

公开(公告)号：US20050175689A1

公开(公告)日：2005-08-11

申请号：US10975210

申请日：2004-10-27

申请人： Ippei Kurimoto ,  Yuki Kasashima ,  Hitoshi Kawai ,  Yuuki Takaishi ,  Masataka Katsuma ,  Hiroshi Ohi ,  Takayuki Yoshida ,  Hiroaki Tasaki

发明人： Ippei Kurimoto ,  Yuki Kasashima ,  Hitoshi Kawai ,  Yuuki Takaishi ,  Masataka Katsuma ,  Hiroshi Ohi ,  Takayuki Yoshida ,  Hiroaki Tasaki

IPC分类号： A61K9/14 ,  A61K9/20

CPC分类号： A61K9/0056 ,  A61K9/2081

摘要： The present invention makes it possible to provide drug-containing coated microparticles for quick-disintegrating oral tablets wherein microparticles containing a drug with an unpleasant taste are coated with a film composed of (1) a pH-independent water-insoluble polymer accounting for 60% or more but less than 80% of the film and (2) a pH-independent water-soluble substance accounting for more than 20% to 40% or less of the film, these microparticles being characterized in that the rate of dissolution of the drug from the drug-containing microparticles is 0% to 10% in one minute and 80% to 100% in 30 minutes, and the average particle diameter is 350 μm or less, in order to realize sufficient control of oral drug dissolution and fast gastrointestinal drug dissolution.

摘要翻译： 本发明使得可以提供用于快速崩解口服片剂的药物包衣微粒，其中含有具有令人不快的味道的药物的微粒被包被（1）不含pH的水不溶性聚合物占60％ 或更多但小于80％的膜，（2）占pH超过20％至40％以下的pH不依赖性水溶性物质，这些微粒的特征在于药物的溶解速率 含药微粒在1分钟内为0％〜10％，30分钟为80％〜100％，平均粒径为350μm以下，为了实现口服药物溶解和快速胃肠药物的充分控制 溶解

公开(公告)号：US20090239791A1

公开(公告)日：2009-09-24

申请号：US12256851

申请日：2008-10-23

申请人： Takayuki Yoshida ,  Kiyo Nakanishi ,  Atsushi Maeda ,  Kazuhiro Sako ,  Yuki Kasashima ,  Hiromu Kondo ,  Tatsunobu Yoshioka ,  Yuuki Tsutsui

发明人： Takayuki Yoshida ,  Kiyo Nakanishi ,  Atsushi Maeda ,  Kazuhiro Sako ,  Yuki Kasashima ,  Hiromu Kondo ,  Tatsunobu Yoshioka ,  Yuuki Tsutsui

IPC分类号： A61K38/13 ,  A61K31/436 ,  A61K31/343

CPC分类号： A61K9/08 ,  A61K31/343 ,  A61K31/365 ,  A61K31/436 ,  A61K38/13 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/44

摘要： A pharmaceutical composition comprising a lipophilic substance which inhibits IL-2 production, and a base capable of inhibiting blood exposure of the substance and delivering the substance to lymph following oral administration, is disclosed. The pharmaceutical composition can inhibit blood exposure of the substance to reduce its adverse effects, and can develop desired pharmacological effects.

摘要翻译： 公开了一种药物组合物，其包含抑制IL-2产生的亲脂性物质，以及能够抑制物质的血液暴露并将其输送到口服给药后的淋巴液的碱。 药物组合物可以抑制物质的血液暴露以减少其不利影响，并且可以产生所需的药理作用。