发明申请
US20050176723A1 (Halo-benzo carbonyl)heterobicyclic p38 kinase inhibiting agents
失效
(卤代 - 苯并羰基)杂双环p38激酶抑制剂
- 专利标题: (Halo-benzo carbonyl)heterobicyclic p38 kinase inhibiting agents
- 专利标题(中): (卤代 - 苯并羰基)杂双环p38激酶抑制剂
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申请号: US10517754申请日: 2003-06-06
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公开(公告)号: US20050176723A1公开(公告)日: 2005-08-11
- 发明人: James Doherty , Swaminathan Natarajan , John Stelmach
- 申请人: James Doherty , Swaminathan Natarajan , John Stelmach
- 国际申请: PCT/US03/17821 WO 20030606
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; A61K31/5377 ; A61P1/04 ; A61P9/10 ; A61P11/00 ; A61P17/02 ; A61P17/04 ; A61P17/06 ; A61P19/02 ; A61P19/06 ; A61P19/08 ; A61P19/10 ; A61P21/00 ; A61P27/02 ; A61P29/00 ; A61P31/04 ; A61P31/12 ; A61P31/18 ; A61P33/06 ; A61P37/06 ; A61P39/02 ; A61P43/00 ; C07D471/04 ; C07D487/02 ; C07D519/00
摘要:
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
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