发明申请
- 专利标题： Method of treating neurodegenerative disease
- 专利标题（中）： 治疗神经变性疾病的方法
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申请号： US10991286申请日： 2004-11-17
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公开(公告)号： US20050186591A1公开(公告)日： 2005-08-25
- 发明人: David Bumcrot , Matthew Farrer , Demetrius Maraganore , Hans-Peter Vornlocher
- 申请人： David Bumcrot , Matthew Farrer , Demetrius Maraganore , Hans-Peter Vornlocher
- 专利权人： Alnylam Pharmaceuticals,Mayo Foundation for Medical Education and Research
- 当前专利权人： Alnylam Pharmaceuticals,Mayo Foundation for Medical Education and Research
- 主分类号： A61K
- IPC分类号： A61K20060101 ; A61K48/00 ; C07H21/02 ; C12N15/113 ; C12Q1/68
摘要：
Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti-SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells.