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公开(公告)号：US20050014173A1
公开(公告)日：2005-01-20
申请号：US10839688
申请日：2004-05-05
申请人： Matthew Farrer
发明人： Matthew Farrer
IPC分类号： C07H21/04 , C12N9/00 , C12Q1/68 , C07K14/705
CPC分类号： C12N9/93 , C07H21/04 , C12Q1/6883 , C12Q2600/156
摘要： Nucleic acids and polypeptides are provided that are associated with PD. Methods and articles of manufacture for screening individuals for susceptibility to PD, including susceptibility to a specific PD phenotype, are also disclosed.
摘要翻译： 提供与PD相关的核酸和多肽。 还公开了筛选个体对PD敏感性的方法和制品，包括对特定PD表型的易感性。
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公开(公告)号：US20070161595A1
公开(公告)日：2007-07-12
申请号：US11548890
申请日：2006-10-12
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3517 , C12N2310/3521
摘要： Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti-SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells.
摘要翻译： 本发明特征的方面涉及用于抑制α-突触核蛋白（SNCA）基因表达的组合物和方法，例如用于治疗神经变性疾病。 本文特征的针对SNCA基因的抗SNCA试剂可以被修饰以改变有利于神经细胞的分布。
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公开(公告)号：US20050186591A1
公开(公告)日：2005-08-25
申请号：US10991286
申请日：2004-11-17
IPC分类号： A61K20060101 , A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3517 , C12N2310/3521
摘要： Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti-SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells.
摘要翻译： 本发明特征的方面涉及用于抑制α-突触核蛋白（SNCA）基因表达的组合物和方法，例如用于治疗神经变性疾病。 本文特征的针对SNCA基因的抗SNCA试剂可以被修饰以改变有利于神经细胞的分布。
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