发明申请
- 专利标题： Novel human thrombopoietin mutein
- 专利标题（中）： 新型人血小板生成素突变蛋白
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申请号： US11043387申请日： 2005-01-26
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公开(公告)号： US20050186603A1公开(公告)日： 2005-08-25
- 发明人: Joo Chung , Sang Kyu Park , Sang Myoung Ju , Hyea Ahn , Seung Wook Lim , Woo Ik Chang , Seung Kook Park , Yeo Wook Koh , Ji Soo Park
- 申请人： Joo Chung , Sang Kyu Park , Sang Myoung Ju , Hyea Ahn , Seung Wook Lim , Woo Ik Chang , Seung Kook Park , Yeo Wook Koh , Ji Soo Park
- 专利权人： Daewoong Pharmaceutical Co., Ltd.
- 当前专利权人： Daewoong Pharmaceutical Co., Ltd.
- 优先权： KR1998-25935 19980630; KR1999-25143 19990629
- 主分类号： C07K14/52
- IPC分类号： C07K14/52 ; C12Q1/68 ; A61K38/18 ; C07K14/475
摘要：
The present invention relates to novel human thrombopoietin (hTPO) derivatives, and to process of preparation thereof. Particularly, sugar chains are introduced into native hTPO by substituting amino acids such as asparagine for amino acids at specific positions in native hTPO, preparing novel hTPO derivatives with high activities enhancing the platelet production in vivo. Therefore, the novel hTPO derivatives of this invention may be useful for the treatment of thrombocytopenia associated with anticancer therapy or the transplantation of bone marrow.
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