发明申请
US20050192230A1 Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine
审中-公开
1- [N 2 - [3,5-二溴-N - [[4-（3,4-二氢-2（1H） - 喹唑啉-3-基）-1-哌啶基]羰基] -D-酪氨酰基 ] -L-赖氨酰基] -4-（4-吡啶基） - 哌嗪
![Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine](/docs/US/2005-09-01/US20050192230A1/abs.jpg.600x600.jpg)
- 专利标题： Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine
- 专利标题（中）： 1- [N 2 - [3,5-二溴-N - [[4-（3,4-二氢-2（1H） - 喹唑啉-3-基）-1-哌啶基]羰基] -D-酪氨酰基 ] -L-赖氨酰基] -4-（4-吡啶基） - 哌嗪
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申请号： US11040273申请日： 2005-01-20
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公开(公告)号： US20050192230A1公开(公告)日： 2005-09-01
- 发明人: Guenter Linz , Wolfgang Broeder , Georg Zerban , Eric Winter , Bernd Schmitt , Svenja Renner , Bjoern Weyell , Heinz-Peter Schmitt
- 申请人： Guenter Linz , Wolfgang Broeder , Georg Zerban , Eric Winter , Bernd Schmitt , Svenja Renner , Bjoern Weyell , Heinz-Peter Schmitt
- 申请人地址： DE Ingelheim
- 专利权人： Boehringer Ingelheim International GambH
- 当前专利权人： Boehringer Ingelheim International GambH
- 当前专利权人地址： DE Ingelheim
- 优先权： DE102004006893 20040212
- 主分类号： A61K38/04
- IPC分类号： A61K38/04 ; C07K5/04
![Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine](/abs-image/US/2005/09/01/US20050192230A1/abs.jpg.150x150.jpg)
摘要：
The present application relates to a process for preparing the CGRP-antagonist 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine of formula by means of which this compound can be prepared in large amounts, in high yields and with high purity.
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