The present invention includes systems, methods, and apparatus configured to close an internal tissue opening, such as an internal tissue opening cased by an atrial septal defect including a patent foramen ovale defect, ventricular septal defect, patent ductus arterosus defect, or the like. For example, a closure device includes a right anchor cooperatively coupled with a left anchor, where the right anchor and left anchor are configured to be positioned about the internal tissue opening. The left and/or right anchor are configured to close the internal tissue opening in one instance, and to provide tissue stimulating or growth-encouraging substances at the tissue opening. Additional aspects of the invention relate to shape, formation, positioning, and detachment of the closure device about the internal tissue opening.