发明申请
- 专利标题: Diamino thiazoloindan derivatives and their use
- 专利标题(中): 二氨基噻唑烷衍生物及其用途
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申请号: US11067110申请日: 2005-02-25
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公开(公告)号: US20050197365A1公开(公告)日: 2005-09-08
- 发明人: Jeffrey Sterling , Liat Hayardeny-Nisimov , David Lerner , Yaacov Herzig , Eliezer Falb , Gyorgy Toth , Sandor Molnar , Dalia Pinkert
- 申请人: Jeffrey Sterling , Liat Hayardeny-Nisimov , David Lerner , Yaacov Herzig , Eliezer Falb , Gyorgy Toth , Sandor Molnar , Dalia Pinkert
- 主分类号: A61K31/428
- IPC分类号: A61K31/428 ; C07D277/84
摘要:
The subject invention provides a compound having the structure: wherein Y is O, NR3R4 or NOR6; R3 is H, alkyl, aralkyl, alkynyl, trifluoroacetyl, t-butoxycarbonyl or an acyl group; R4 is H, alkyl, aralkyl, or alkynyl; R6 is H or C1-C4 alkyl; R1 and R2 are each independently H, alkyl, aralkyl, or alkynyl; the curved line drawn from S to the center of the phenyl ring and the straight line drawn from N to the center of the ring indicate that S and N are part of a 5 membered ring which shares two carbons with the phenyl ring; and the dashed line drawn from the carbon atom on the cyclopentyl ring to Y represents a bond when Y is O or NOR6 and is absent when Y is NR3R4, and wherein wherein X is H or O; and R5 is H, alkyl, trifluoroacetyl, t-butoxycarbonyl or an acyl group, or an enantiomer, or a tautomer, or a pharmaceutically acceptable salt thereof, a process for preparing the compounds and a method of treating Parknison's disease, multiple sclerosis or depression with the compounds of the invention.
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