发明申请
- 专利标题： Inhibitors of protein tyrosine phosphatase 1B
- 专利标题（中）： 蛋白酪氨酸磷酸酶1B抑制剂
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申请号： US11063475申请日： 2005-02-23
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公开(公告)号： US20050203087A1公开(公告)日： 2005-09-15
- 发明人: Jinbo Lee , Zhao-Kui Wan , Douglas Wilson , Bruce Follows , Steven Kirincich , Michael Smith , Jun-Jun Wu , Kenneth Foreman , David Erbe , Yan-Ling Zhang , Weixin Xu , Steve Tam
- 申请人： Jinbo Lee , Zhao-Kui Wan , Douglas Wilson , Bruce Follows , Steven Kirincich , Michael Smith , Jun-Jun Wu , Kenneth Foreman , David Erbe , Yan-Ling Zhang , Weixin Xu , Steve Tam
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; A61K31/4025 ; A61K31/4178 ; A61K31/453 ; A61K31/496 ; A61K31/5377 ; A61K31/541
摘要：
Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
公开/授权文献
- US07521473B2 Inhibitors of protein tyrosine phosphatase 1B 公开/授权日：2009-04-21
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