公开(公告)号：US20070197770A1

公开(公告)日：2007-08-23

申请号：US10594757

申请日：2005-03-30

Applicant: Kazuhiro Hikida ,  Hirotaka Kutami ,  Naoyuki Kobayashi ,  David Erbe

Inventor： Kazuhiro Hikida ,  Hirotaka Kutami ,  Naoyuki Kobayashi ,  David Erbe

IPC: C08F6/00

CPC classification number: C08C1/14 ,  B01F7/00766 ,  B01J2219/00006 ,  B29B7/402 ,  C08C1/15 ,  C08F6/22

Abstract: A method of production of a rubbery polymer by adding a coagulating agent to a polymer latex to make the rubbery polymer ingredient coagulate, the method of production of a rubbery polymer having a step of using a crusher pump to make the rubbery polymer ingredient coagulate to obtain a crumb slurry, using as the crusher pump a pump having a head of 10 m or more. According to this invention, in a method of production of a rubbery polymer by adding a coagulating agent to a polymer latex to make the rubbery polymer ingredient coagulate, an improvement of the operation efficiency and a reduction of the production process and production equipment are made possible and a reduction of the equipment costs and a reduction of the production costs can be achieved.

Abstract translation: 一种通过向聚合物胶乳中加入凝固剂以使橡胶状聚合物成分凝固而制备橡胶状聚合物的方法，制备橡胶状聚合物的方法，该橡胶状聚合物具有使用破碎机泵使凝胶化聚合物成分凝固的步骤 使用具有10μm或更大的头的泵作为破碎泵使用的碎屑浆料。 根据本发明，在通过向聚合物胶乳中添加凝结剂以使橡胶状聚合物成分凝固的橡胶状聚合物的制造方法中，可以提高操作效率和减少生产工艺和生产设备 可以实现设备成本的降低和生产成本的降低。

公开(公告)号：US20050203087A1

公开(公告)日：2005-09-15

申请号：US11063475

申请日：2005-02-23

Applicant: Jinbo Lee ,  Zhao-Kui Wan ,  Douglas Wilson ,  Bruce Follows ,  Steven Kirincich ,  Michael Smith ,  Jun-Jun Wu ,  Kenneth Foreman ,  David Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Tam

Inventor： Jinbo Lee ,  Zhao-Kui Wan ,  Douglas Wilson ,  Bruce Follows ,  Steven Kirincich ,  Michael Smith ,  Jun-Jun Wu ,  Kenneth Foreman ,  David Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Tam

IPC: A61K31/381 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/453 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541

CPC classification number: C07D333/38 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D451/02

Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.

Abstract translation: 蛋白酪氨酸磷酸酶（PTPases）如PTP1B可以在调节各种细胞反应（如胰岛素信号）中发挥作用。 取代的噻吩化合物例如2-羧基，3-羧基甲氧基，5-芳基取代的噻吩可以抑制PTP1B，从而诱导更大的胰岛素敏感性。 因此，PTP1B抑制可以为PTPase介导的病症例如糖尿病提供替代治疗。

公开(公告)号：US20060135488A1

公开(公告)日：2006-06-22

申请号：US11285223

申请日：2005-11-22

Applicant: Jinbo Lee ,  Michael Smith ,  Alessandro Moretto ,  Zhao-Kui Wan ,  Eva Binnun ,  Weixin Xu ,  Kenneth Foreman ,  Diane Joseph-McCarthy ,  David Erbe ,  Steve Tam

Inventor： Jinbo Lee ,  Michael Smith ,  Alessandro Moretto ,  Zhao-Kui Wan ,  Eva Binnun ,  Weixin Xu ,  Kenneth Foreman ,  Diane Joseph-McCarthy ,  David Erbe ,  Steve Tam

IPC: A61K31/4743 ,  A61K31/453 ,  A61K31/382 ,  C07D495/02 ,  C07D498/02

CPC classification number: C07D495/04 ,  C07D333/70 ,  C07D333/74

Abstract: This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1B (PTP1B).

Abstract translation: 本发明涉及调节（例如抑制）蛋白质酪氨酸磷酸酶1B（PTP1B）。

公开(公告)号：US20050203081A1

公开(公告)日：2005-09-15

申请号：US11064390

申请日：2005-02-23

Applicant: Jinbo Lee ,  Steve Kirincich ,  Michael Smith ,  Douglas Wilson ,  Bruce Follows ,  Zhao-Kui Wan ,  Diane Joseph-McCarthy ,  David Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Tam

Inventor： Jinbo Lee ,  Steve Kirincich ,  Michael Smith ,  Douglas Wilson ,  Bruce Follows ,  Zhao-Kui Wan ,  Diane Joseph-McCarthy ,  David Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Tam

IPC: A61K31/381 ,  A61K31/407 ,  A61K31/4743 ,  A61K31/55 ,  C07D333/70 ,  C07D495/04 ,  C07D498/02

CPC classification number: C07D495/04 ,  C07D333/70

Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.

Abstract translation: 蛋白酪氨酸磷酸酶（PTPases）如PTP1B可以在调节各种细胞反应（如胰岛素信号）中发挥作用。 取代的双环稠合噻吩化合物可以抑制PTP1B，从而诱导更大的胰岛素敏感性。 因此，PTP1B抑制可以为PTPase介导的病症例如糖尿病提供替代治疗。