Invention Application
- Patent Title: Novel polymers for delivering nitric oxide in vivo
- Patent Title (中): 用于在体内递送一氧化氮的新型聚合物
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Application No.: US11053593Application Date: 2005-02-08
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Publication No.: US20050220756A1Publication Date: 2005-10-06
- Inventor: Jonathan Stamler , Eric Toone , Richard Stack
- Applicant: Jonathan Stamler , Eric Toone , Richard Stack
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Main IPC: A61L27/00
- IPC: A61L27/00 ; A61K31/785 ; A61K47/48 ; A61L29/00 ; A61L31/10 ; A61L31/16 ; A61L33/00 ; A61L33/06 ; A61L33/08 ; C08B37/00 ; C08B37/16 ; C08G75/00 ; C08G75/14
Abstract:
Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.
Public/Granted literature
- US07087709B2 Polymers for delivering nitric oxide in vivo Public/Granted day:2006-08-08
Information query
