发明申请
- 专利标题: Integrin linked kinase modulation of macrophage activation
- 专利标题(中): 整合素联合激酶调节巨噬细胞活化
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申请号: US10163599申请日: 2002-06-05
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公开(公告)号: US20050220779A1公开(公告)日: 2005-10-06
- 发明人: Ljiljana Kojic , Patricia Logan , Jeffery Wheeler , Kymberley Sutton , Gabriel Kalmar
- 申请人: Ljiljana Kojic , Patricia Logan , Jeffery Wheeler , Kymberley Sutton , Gabriel Kalmar
- 主分类号: A61K31/00
- IPC分类号: A61K31/00 ; A61K31/415 ; A61K31/44 ; A61K38/45 ; C12N9/12
摘要:
Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the binding of natural ILK ligands to ILK; or compounds that prevent expression of, or signaling through ILK exert an anti-inflammatory effect by inhibiting iNOS and COX-2 expression, at the level of transcription by suppressing the activation of NF-κB. The modulation of activation through ILK is used to regulate immune processes at targeted sites, for example to decrease undesirable inflammatory responses.
公开/授权文献
- US07504228B2 Integrin linked kinase modulation of monocyte activation 公开/授权日:2009-03-17