公开(公告)号：US20070088075A1

公开(公告)日：2007-04-19

申请号：US11581225

申请日：2006-10-13

申请人： Doug Chou ,  Bertrand Plouvier ,  Peter Pang ,  James Yee ,  Jeffery Wheeler ,  Aregahegn Yifru ,  Allen Davidoff

发明人： Doug Chou ,  Bertrand Plouvier ,  Peter Pang ,  James Yee ,  Jeffery Wheeler ,  Aregahegn Yifru ,  Allen Davidoff

IPC分类号： A61K31/4015

CPC分类号： C07D207/12

摘要： This invention is directed to deuterated aminocyclohexyl ether compounds and processes for preparing same and methods of using same.

摘要翻译： 本发明涉及氘代氨基环己基醚化合物及其制备方法及其使用方法。

公开(公告)号：US20050220779A1

公开(公告)日：2005-10-06

申请号：US10163599

申请日：2002-06-05

申请人： Ljiljana Kojic ,  Patricia Logan ,  Jeffery Wheeler ,  Kymberley Sutton ,  Gabriel Kalmar

发明人： Ljiljana Kojic ,  Patricia Logan ,  Jeffery Wheeler ,  Kymberley Sutton ,  Gabriel Kalmar

IPC分类号： A61K31/00 ,  A61K31/415 ,  A61K31/44 ,  A61K38/45 ,  C12N9/12

CPC分类号： A61K31/135 ,  A61K31/00 ,  A61K31/415 ,  A61K31/435 ,  A61K31/44

摘要： Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the binding of natural ILK ligands to ILK; or compounds that prevent expression of, or signaling through ILK exert an anti-inflammatory effect by inhibiting iNOS and COX-2 expression, at the level of transcription by suppressing the activation of NF-κB. The modulation of activation through ILK is used to regulate immune processes at targeted sites, for example to decrease undesirable inflammatory responses.

摘要翻译： 提供方法来特异性调节单核细胞和/或巨噬细胞的活化。 整合素连接激酶（ILK）阻断剂的施用; 否则阻止天然ILK配体结合ILK的化合物; 或者通过抑制NF-κB的活化来防止ILK的表达或通过ILK信号通过抑制iNOS和COX-2表达在转录水平发挥抗炎作用的化合物。 通过ILK的激活调节用于调节靶向部位的免疫过程，例如减少不良的炎性反应。

公开(公告)号：US20050079212A1

公开(公告)日：2005-04-14

申请号：US10956425

申请日：2004-10-01

申请人： Jeffery Wheeler ,  Michael Hope ,  Pieter Cullis ,  Marcel Bally

发明人： Jeffery Wheeler ,  Michael Hope ,  Pieter Cullis ,  Marcel Bally

IPC分类号： A61K9/127 ,  C12N15/88

CPC分类号： C12N15/88 ,  A61K9/1272 ,  Y10S436/829 ,  Y10S514/851 ,  Y10S977/80 ,  Y10S977/907

摘要： Plasmid-lipid particles which are useful for transfection of cells in vitro or in vivo are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. The particles are typically 65-85 nm, fully encapsulate the plasmid and are serum-stable.

摘要翻译： 描述了可用于体外或体内转染细胞的质粒 - 脂质颗粒。 可以使用洗涤剂透析方法或利用有机溶剂的方法形成颗粒。 颗粒通常为65-85nm，完全包封质粒并且是血清稳定的。

公开(公告)号：US06344359B1

公开(公告)日：2002-02-05

申请号：US09360480

申请日：1999-07-23

申请人： Jeffery Wheeler ,  Zaihui Zhang

发明人： Jeffery Wheeler ,  Zaihui Zhang

IPC分类号： G01N3320

CPC分类号： G01N31/22

摘要： A rapid colorimetric assay is provided for determining the concentration of vanadyl and vanadate ion species, and total vanadium concentration, in a sample. A sample suspected of containing vanadium in one or more of these oxidation states is combined with a colorimetric substrate that will provide for different absorption spectra with vanadyl and vanadate complexes. Suitable colorimetric substrates include halogenated hydroxyquinolines, e.g. broxyquinoline (DBHQ). The solvent and assay conditions are chosen to minimize oxidation of the vanadium. The absorbance of the sample is then read at two wavelengths, one that indicates the presence of both vanadyl and vanadate, and one that indicates the presence only of one species, generally vanadate. By comparison to a standard curve, the total concentration and the species concentration of vanadium in the sample is determined.

摘要翻译： 提供了一种快速比色测定法，用于测定样品中氧钒和钒酸根离子种类的浓度以及总钒浓度。 怀疑含有一种或多种这些氧化态的钒的样品与比色底物结合，其将提供与氧钒和钒酸盐络合物不同的吸收光谱。 合适的比色底物包括卤代羟基喹啉，例如 氨基喹啉（DBHQ）。 选择溶剂和测定条件以使钒的氧化最小化。 然后在两个波长上读取样品的吸光度，其中一个表示氧钒和钒酸盐的存在，一个表示仅存在一种物质，通常为钒酸盐。 与标准曲线相比，测定样品中钒的总浓度和物质浓度。