发明申请
- 专利标题： Topical anhydrous and ethanol-free ascomycin compositions
- 专利标题（中）： 局部无水和无乙醇的青霉素组合物
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申请号： US10523750申请日： 2003-08-13
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公开(公告)号： US20050220850A1公开(公告)日： 2005-10-06
- 发明人: Dorothea Ledergerber , Jean-Claude Sonntag , Katrin Kriwet , Nabila Sekkat
- 申请人： Dorothea Ledergerber , Jean-Claude Sonntag , Katrin Kriwet , Nabila Sekkat
- 优先权： GB0218996.7 20020814
- 国际申请： PCT/EP03/08999 WO 20030813
- 主分类号： A61K9/06
- IPC分类号： A61K9/06 ; A61K9/10 ; A61K31/445 ; A61K31/706 ; A61K47/02 ; A61K47/04 ; A61K47/06 ; A61K47/10 ; A61K47/14 ; A61K47/26 ; A61K47/38 ; A61K47/44 ; A61K47/46 ; A61P17/00 ; A61K31/33 ; A61K9/00
摘要：
Single-phase topical liquid or semi-solid pharmaceutical compositions substantially free of ethanol and water and comprising an ascomycin, such as pimecrolimus, in a carrier vehicle comprising a 3-component solvent mixture amounting to at least 40% w/w of the total weight of the composition and consisting of: i) a C3-8 alkanol and/or C1-8 alkanediol; ii) a fatty alcohol; and iii) a further solvent selected from: a) an alkane carboxylic acid alkyl ester and/or alkane dicarboxylic acid alkyl ester and/or b) a hydrophilic co-component and/or c) a triglyceride; and optionally further conventional excipients.
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