发明申请
US20050227960A1 Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
有权
取代的双环烷基胺衍生物作为趋化因子受体活性的调节剂
- 专利标题： Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
- 专利标题（中）： 取代的双环烷基胺衍生物作为趋化因子受体活性的调节剂
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申请号： US11060250申请日： 2005-02-17
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公开(公告)号： US20050227960A1公开(公告)日： 2005-10-13
- 发明人: Douglas Batt , Percy Carter
- 申请人： Douglas Batt , Percy Carter
- 主分类号： A61K31/4035
- IPC分类号： A61K31/4035 ; A61K31/454 ; A61K31/4709 ; A61K31/5377 ; A61K31/55 ; C07D209/52 ; C07D403/12 ; C07D413/02 ; C07D43/02
摘要：
The present application describes modulators of MCP-1 of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein X, Z, a, b, c, d, n, R1, R2, R3, R4, R5, R10, R10a, and R12, are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using said modulators are disclosed.
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