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18 条记录 (耗时 0.025 秒)

    Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
    2.
    发明申请
    Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity 有权
    取代的双环烷基胺衍生物作为趋化因子受体活性的调节剂

    公开(公告)号：US20050227960A1

    公开(公告)日：2005-10-13

    申请号：US11060250

    申请日：2005-02-17

    申请人： Douglas Batt ,  Percy Carter

    发明人： Douglas Batt ,  Percy Carter

    IPC分类号： A61K31/4035 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/55 ,  C07D209/52 ,  C07D403/12 ,  C07D413/02 ,  C07D43/02

    CPC分类号： C07D209/52 ,  C07D403/12

    摘要： The present application describes modulators of MCP-1 of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein X, Z, a, b, c, d, n, R1, R2, R3, R4, R5, R10, R10a, and R12, are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using said modulators are disclosed.

    摘要翻译： 本申请描述了式（I）的MCP-1的调节剂：其立体异构体或其药学上可接受的盐，其中X，Z，a，b，c，d，n，R 1， R 2，R 3，R 4，R 5，R 10，R 10， SUP＆gt; 10a＆lt;＆lt;＆lt; 12＆gt;，如本文所定义。 此外，公开了使用所述调节剂治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫病态如类风湿性关节炎和动脉粥样硬化的方法。

    Substituted fused bicyclic amines as modulators of chemokine receptor activity
    3.
    发明申请
    Substituted fused bicyclic amines as modulators of chemokine receptor activity 有权
    取代的稠合双环胺作为趋化因子受体活性的调节剂

    公开(公告)号：US20050197373A1

    公开(公告)日：2005-09-08

    申请号：US11060483

    申请日：2005-02-17

    申请人： Douglas Batt ,  Percy Carter ,  Dean Wacker

    发明人： Douglas Batt ,  Percy Carter ,  Dean Wacker

    IPC分类号： A61K31/4035 ,  A61K31/41 ,  C07D209/44 ,  C07D43/02

    CPC分类号： C07D403/12 ,  C07D217/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/10

    摘要： The present application describes modulators of CCR3 of formula (Ia) and (Ib): or pharmaceutically acceptable salt forms thereof, wherein Z, R1, R2, R3, R4, R5, R5′, R6, a, b, c, d, and u are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using said modulators are disclosed.

    摘要翻译： 本申请描述了式（Ia）和（Ib）的CCR3的调节剂：或其药学上可接受的盐形式，其中Z，R 1，R 2，R SUP R 3，R 4，R 5，R 5，R 6，S 6， b，c，d和u如本文所定义。 此外，公开了使用所述调节剂治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫病态如类风湿性关节炎和动脉粥样硬化的方法。

    Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
    5.
    发明申请
    Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity 有权
    取代的双环烷基胺衍生物作为趋化因子受体活性的调节剂

    公开(公告)号：US20050192276A1

    公开(公告)日：2005-09-01

    申请号：US11059771

    申请日：2005-02-17

    申请人： Douglas Batt ,  Percy Carter

    发明人： Douglas Batt ,  Percy Carter

    IPC分类号： A61K31/4035 ,  A61K31/5377 ,  C07D413/14

    CPC分类号： C07D403/14 ,  C07D403/04

    摘要： The present application describes modulators of MCP-1 of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein X, Z, a, b, c, d, bond g, n, s, R1, R2, R4, R5, R10, R12, and R13, are as defined above. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using said modulators are disclosed.

    摘要翻译： 本申请描述了式（I）的MCP-1的调节剂：其立体异构体或其药学上可接受的盐，其中X，Z，a，b，c，d，键g，n，s，R 1， R 2，R 2，R 4，R 5，R 10，R 12， SUP>和R 13，如上所定义。 此外，公开了使用所述调节剂治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫病态如类风湿性关节炎和动脉粥样硬化的方法。

    Process of preparing N-ureidoalkyl-piperidines
    6.
    发明申请
    Process of preparing N-ureidoalkyl-piperidines 失效
    制备N-脲基烷基 - 哌啶的方法

    公开(公告)号：US20050277666A1

    公开(公告)日：2005-12-15

    申请号：US11149410

    申请日：2005-06-09

    申请人： Percy Carter

    发明人： Percy Carter

    IPC分类号： A61K31/445 ,  C07D211/18 ,  C07D211/26

    CPC分类号： C07D211/18 ,  Y02P20/55

    摘要： The present application describes a process of preparing a compound of formula (IV), or salt or stereoisomer thereof: wherein Pg, at each occurrence, is independently selected from an amine protecting group; comprising the steps of reacting a compound of Formula with a reducing agent to give a compound of Formula III: reacting the compound of formula (III) with an amine of formula (IIa) using reductive amination to give the compound of formula (III)

    摘要翻译： 本申请描述了制备式（IV）化合物或其盐或立体异构体的方法：其中P g在每次出现时独立地选自胺保护基; 包括使式的化合物与还原剂反应得到式III化合物的步骤：使式（IIIa）的化合物与式（IIa）的胺反应，使用还原胺化得到式（III）的化合物，

    Chimeric chemokine receptor polypeptides
    10.
    发明申请
    Chimeric chemokine receptor polypeptides 有权
    嵌合趋化因子受体多肽

    公开(公告)号：US20050123972A1

    公开(公告)日：2005-06-09

    申请号：US10988267

    申请日：2004-11-12

    申请人： Joseph Dinchuk ,  Paul Davies ,  Qihong Zhao ,  Percy Carter ,  Kimberly Solomon ,  Peggy Scherle

    发明人： Joseph Dinchuk ,  Paul Davies ,  Qihong Zhao ,  Percy Carter ,  Kimberly Solomon ,  Peggy Scherle

    IPC分类号： C07H21/04 ,  C07K14/715 ,  C12N20060101 ,  C12N15/62 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567

    CPC分类号： C07K14/7158 ,  C12N15/62

    摘要： The present invention relates to a chimeric chemokine receptor comprising two components: a first sequence comprising the N terminus through the last residue of the seven helix TM region of a first chemokine receptor joined with a second sequence comprising the C terminus of a second chemokine receptor extending from the first intracellular residue of the chemokine receptor to the last residue of the chemokine receptor. The chimeric chemokine receptor can be employed in various applications, such as ligand binding and screening assays and signalling assays. The chimeric chemokine receptor can also form a component of a chemokine receptor modulator design program.

    摘要翻译： 本发明涉及包含两个组分的嵌合趋化因子受体：包含第一趋化因子受体的七个螺旋TM区域的最后残基的N末端的第一序列与第二序列连接，第二序列包含延伸的第二趋化因子受体的C末端 从趋化因子受体的第一个细胞内残基到趋化因子受体的最后残基。 嵌合趋化因子受体可用于各种应用，例如配体结合和筛选测定和信号测定。 嵌合趋化因子受体还可以形成趋化因子受体调节剂设计程序的组分。