发明申请
US20050239725A1 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
有权
从1-酰基 - 烷基衍生物合成前药的方法及其组合物
- 专利标题： Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
- 专利标题（中）： 从1-酰基 - 烷基衍生物合成前药的方法及其组合物
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申请号： US11158405申请日： 2005-06-21
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公开(公告)号： US20050239725A1公开(公告)日： 2005-10-27
- 发明人: Mark Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat , Cindy Zhou
- 申请人： Mark Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat , Cindy Zhou
- 专利权人： XenoPort, Inc.
- 当前专利权人： XenoPort, Inc.
- 主分类号： C07C271/12
- IPC分类号： C07C271/12 ; C07C271/22 ; C07F9/40 ; A61K31/704 ; A61K31/325 ; A61K31/445 ; A61K31/496
摘要：
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
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