发明申请
- 专利标题: Alkynylated fused ring pyrimidine compounds
- 专利标题(中): 炔烃基稠环嘧啶化合物
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申请号: US11148880申请日: 2005-06-09
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公开(公告)号: US20050245548A1公开(公告)日: 2005-11-03
- 发明人: Bernard Gaudilliere , Henri Jacobelli , Joseph Picard , Michael Wilson
- 申请人: Bernard Gaudilliere , Henri Jacobelli , Joseph Picard , Michael Wilson
- 优先权: WOPCT/EP01/11824 20011012; WOPCT/EP02/08475 20020712
- 主分类号: A61K31/517
- IPC分类号: A61K31/517 ; A61K31/519 ; A61P1/02 ; A61P1/04 ; A61P9/04 ; A61P9/10 ; A61P11/00 ; A61P11/06 ; A61P17/06 ; A61P19/02 ; A61P19/10 ; A61P27/00 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07D239/96 ; C07D403/06 ; C07D471/04 ; C07D487/04 ; C07D521/00 ; C07F7/18
摘要:
A compound selected from those of formula (I): wherein W1 represents O, S, or —NR3 in which R3 represents hydrogen, alkyl, OH or CN; W2 represents a group selected from hydrogen, CF3, NH2, monoalkylamino, dialkylamino, alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkylalkyl, heterocycle, these groups being optionally substituted, or W1 and W2 form together a group of formula —N═X4—W3— as defined in the description, X1, X2 and X3 represent N or C optionally substituted, n is 0 to 8, Z represents —CR12R13, wherein R12 and R13 are as defined in the description, A represents a ring system, the groups R2 represent hydrogen or various chemical groups as defined in the description, q is 0 to 7; R1 represents hydrogen, alkyl, alkenyl, alkynyl, or a ring system, and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix metalloprotease.
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