A method and apparatus selects serving scheduling Node B for efficiently controlling and scheduling uplink traffic transmission from user equipments (UEs) located in a soft handover region. The UE selects a serving scheduling cell among cells included in its active set and transmits information on the selected serving scheduling cell to a Node B through uplink signaling. A service scheduling cell and non-serving scheduling cells efficiently control uplink traffic from the UE through independent scheduling. The efficient use of uplink resources contributes to an increase in the entire system performance and system stability.