发明申请
US20050250133A1 Molecular interaction sites of 16S ribosomal RNA and methods of modulating the same
审中-公开
16S核糖体RNA的分子相互作用位点及其调控方法
- 专利标题： Molecular interaction sites of 16S ribosomal RNA and methods of modulating the same
- 专利标题（中）： 16S核糖体RNA的分子相互作用位点及其调控方法
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申请号： US11070519申请日： 2005-03-01
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公开(公告)号： US20050250133A1公开(公告)日： 2005-11-10
- 发明人: David Ecker , Steven Hofstadler , Richard Griffey , Rangarajan Sampath , Kristin Lowery , Christian Massire
- 申请人： David Ecker , Steven Hofstadler , Richard Griffey , Rangarajan Sampath , Kristin Lowery , Christian Massire
- 主分类号： C12N5/02
- IPC分类号： C12N5/02 ; C12N15/11 ; C12Q1/68 ; G01N33/48 ; G01N33/50 ; G06F19/00
摘要：
Polynucleotides comprising molecular interaction sites of 16S rRNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of 16S rRNA by contacting 16S rRNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.
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