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1.发明申请Molecular interaction sites of 16S ribosomal RNA and methods of modulating the same 审中-公开16S核糖体RNA的分子相互作用位点及其调控方法公开(公告)号：US20050250133A1
公开(公告)日：2005-11-10
申请号：US11070519
申请日：2005-03-01
申请人： David Ecker , Steven Hofstadler , Richard Griffey , Rangarajan Sampath , Kristin Lowery , Christian Massire
发明人： David Ecker , Steven Hofstadler , Richard Griffey , Rangarajan Sampath , Kristin Lowery , Christian Massire
CPC分类号： C12N15/11
摘要： Polynucleotides comprising molecular interaction sites of 16S rRNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of 16S rRNA by contacting 16S rRNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.
摘要翻译： 提供了包含具有特定二级结构的16S rRNA的分子相互作用位点的多核苷酸。 还提供了使用这样的多核苷酸筛选，实际上或实际上筛选结合其的化合物的组合文库的方法。 还提供了通过将含有该酶的16S rRNA或原核细胞与通过这种虚拟或实际筛选鉴定的化合物接触来调节16S rRNA活性的方法。
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2.发明申请Compositions and methods for the treatment of severe acute respiratory syndrome (SARS) 有权治疗严重急性呼吸综合征（SARS）的组合物和方法公开(公告)号：US20050100885A1
公开(公告)日：2005-05-12
申请号：US10831901
申请日：2004-04-26
申请人： Stanley Crooke , David Ecker , Rangarajan Sampath , Susan Freier , Christian Massire , Steven Hofstadler , Kristin Lowery , Eric Swayze , Brenda Baker , C. Bennett
发明人： Stanley Crooke , David Ecker , Rangarajan Sampath , Susan Freier , Christian Massire , Steven Hofstadler , Kristin Lowery , Eric Swayze , Brenda Baker , C. Bennett
IPC分类号： A01N43/04 , A61B20060101 , A61K31/07 , A61K48/00 , C07H21/02 , C07H21/04 , C07K16/10 , C12N15/113 , C12Q1/68 , C12Q1/70
CPC分类号： C12N15/1131 , C07K16/10 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associated diseases.
摘要翻译： 本发明提供可以施用以降低SARS病毒在体内或体外的活性，预防或治疗SARS病毒相关疾病，检测AARS病毒和诊断SARS病毒的寡聚化合物和组合物的设计和合成， 相关疾病
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公开(公告)号：US20050266397A1
公开(公告)日：2005-12-01
申请号：US10829826
申请日：2004-04-22
申请人： David Ecker , Steven Hofstadler , Rangarajan Sampath , Lawrence Blyn , Thomas Hall , Christian Massire
发明人： David Ecker , Steven Hofstadler , Rangarajan Sampath , Lawrence Blyn , Thomas Hall , Christian Massire
IPC分类号： C12N20060101 , C12N15/00 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/701 , C12N2770/20011 , Y10T436/24
摘要： The present invention provides a method for rapid identification and quantitation of bacteria by amplification of a segment of bacterial nucleic acid followed by analysis by mass spectrometry. The compositions provide for characterization of the molecular masses and base compositions of bacterial nucleic acids which are used to rapidly identify bacteria.
摘要翻译： 本发明提供了通过扩增细菌核酸片段，然后通过质谱法分析来快速鉴定和定量细菌的方法。 该组合物提供用于快速鉴定细菌的细菌核酸的分子量和碱性组成的表征。
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公开(公告)号：US20060121520A1
公开(公告)日：2006-06-08
申请号：US11331987
申请日：2006-01-13
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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5.发明申请公开(公告)号：US20070048735A1
公开(公告)日：2007-03-01
申请号：US10660997
申请日：2003-09-12
申请人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke , James Hannis
发明人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke , James Hannis
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译： 本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。 该方法也可用于通过基因分型生物学的流行病学调查。
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6.发明申请Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 审中-公开定义数据库的二级结构和用于确定未知生物标签的身份和地理起源的方法公开(公告)号：US20050027459A1
公开(公告)日：2005-02-03
申请号：US10439706
申请日：2003-05-16
申请人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke
发明人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke
IPC分类号： A61B20060101 , C12P19/34 , C12Q1/68 , C12Q1/70 , G01N31/00 , G01N33/48 , G01N33/50 , G06F19/00 , G06F19/18
摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
摘要翻译： 本发明一般涉及研究生物信息学领域，更具体地涉及定义数据库的二级结构。 本发明还涉及询问数据库作为已知生物标签的分子量来源的方法，用于与未知或选择的生物标签的分子量进行比较以确定所选择的生物标签的身份，和/或确定所选生物标记的来源 所选的生物标签。 生物制剂的鉴定对于在诸如生物战争的情况下确定生物制剂的适当治疗过程和/或辐照是重要的。 此外，确定所选择的生物制剂的地理起源将有助于确定潜在的犯罪认同。
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公开(公告)号：US20060275788A1
公开(公告)日：2006-12-07
申请号：US11331978
申请日：2006-01-13
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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公开(公告)号：US20060259249A1
公开(公告)日：2006-11-16
申请号：US11073362
申请日：2005-03-03
申请人： Rangarajan Sampath , Vivek Samant , Christian Massire , Harold Levene , David Ecker , John McNeil
发明人： Rangarajan Sampath , Vivek Samant , Christian Massire , Harold Levene , David Ecker , John McNeil
IPC分类号： G06F19/00
摘要： The method described herein relate generally the identification of bioagents on the basis of base composition signatures for bioagent-identifying amplicons. Specifically, methods of the present invention are directed to the application of pattern recognition models, particularly probability pattern classifiers, to the identification of both known and previously unrecognized bioagents. In certain embodiments, the pattern classifiers relate to probability cloud patterns, such as mutational probability patterns. In other embodiments the pattern classifiers relate to polytope pattern models.
摘要翻译： 本文所述的方法一般涉及基于用于生物鉴别扩增子的碱基组成特征的生物标记的鉴定。 具体地，本发明的方法涉及模式识别模型，特别是概率模式分类器在识别已知和以前未被认识的生物标签的应用。 在某些实施例中，模式分类器涉及概率云模式，例如突变概率模式。 在其他实施例中，模式分类器涉及多面体图案模型。
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9.发明申请公开(公告)号：US20070218467A1
公开(公告)日：2007-09-20
申请号：US11491376
申请日：2006-07-21
申请人： David Ecker , Steven Hofstadler , Thomas Hall , Kristin Lowery
发明人： David Ecker , Steven Hofstadler , Thomas Hall , Kristin Lowery
CPC分类号： C12Q1/6872 , C12Q1/6827 , C12Q1/6844 , C12Q1/6858 , C12Q1/6881 , C12Q2600/156 , C12Q2600/16 , C12Q2565/627 , C12Q2537/143 , C12Q2531/113 , C12Q2545/10
摘要： There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products.
摘要翻译： 需要具有特异性和快速性的核酸分析，并且其中不需要核酸测序。 本发明除了提供核酸扩增核酸扩增方法之外，还通过质谱法对所得扩增产物进行分子量测定，以及确定扩增产物的碱基组成来解决这一需要。
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公开(公告)号：US20060275749A1
公开(公告)日：2006-12-07
申请号：US11210516
申请日：2005-08-24
CPC分类号： C12Q1/701 , C12Q1/6888
摘要： Oligonucleotide primers and compositions and kits containing the same for rapid identification of orthopoxviruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis are provided.
摘要翻译： 提供了通过扩增一段病毒核酸，随后进行分子质量分析的寡核苷酸引物和包含其的组合物和试剂盒，用于快速鉴定正痘病毒。
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