发明申请
US20050250706A1 Processes for the preparation of alpha polymorph of perindopril erbumine
审中-公开
培哚普林卵白素α多晶型物的制备方法
- 专利标题： Processes for the preparation of alpha polymorph of perindopril erbumine
- 专利标题（中）： 培哚普林卵白素α多晶型物的制备方法
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申请号： US11122731申请日： 2005-05-05
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公开(公告)号： US20050250706A1公开(公告)日： 2005-11-10
- 发明人: Narendra Joshi , Shekhar Bhirud , Kodali Rao
- 申请人： Narendra Joshi , Shekhar Bhirud , Kodali Rao
- 申请人地址： IN Mumbai
- 专利权人： Glenmark Pharmaceuticals Limited
- 当前专利权人： Glenmark Pharmaceuticals Limited
- 当前专利权人地址： IN Mumbai
- 优先权： IN531/MUM/2004 20040507
- 主分类号： A61K31/405
- IPC分类号： A61K31/405 ; A61K38/04 ; C07D209/42 ; C07K5/02
摘要：
Processes for the preparation of an alpha polymorph of perindopril erbumine is provided comprising (a) forming a solution comprising perindopril erbumine in one or more ketones; (b) heating the solution to reflux; and (c) cooling the solution to a temperature sufficient to form the alpha polymorph of perindopril erbumine. The alpha polymorphs of perindopril erbumine obtained herein have a high purity level.
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