发明申请
- 专利标题： Substituted piperazines
- 专利标题（中）： 取代的哌嗪
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申请号： US10979882申请日： 2004-11-01
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公开(公告)号： US20050256130A1公开(公告)日： 2005-11-17
- 发明人: Andrew Pennell , James Aggen , J.J. Wright , Subhabrata Sen , Brian McMaster , Daniel Dairaghi , Wei Chen , Penglie Zhang
- 申请人： Andrew Pennell , James Aggen , J.J. Wright , Subhabrata Sen , Brian McMaster , Daniel Dairaghi , Wei Chen , Penglie Zhang
- 申请人地址： US CA Mountain View
- 专利权人： ChemoCentryx, Inc.
- 当前专利权人： ChemoCentryx, Inc.
- 当前专利权人地址： US CA Mountain View
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K31/506 ; C07D231/12 ; C07D231/16 ; C07D231/18 ; C07D231/38 ; C07D231/56 ; C07D401/04 ; C07D401/12 ; C07D403/04 ; C07D405/04 ; C07D409/04 ; C07D413/14 ; C07D43/14
摘要：
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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