Methods of cooling and sanitation of target items, particularly food products, food storage, and food transportation devices. A treating agent containing a sanitizing agent entrapped by or absorbed in or on a cooling agent is used when processing, transporting, displaying, or storing of target items. The treating agent can be used to chill and preserve target items, and while providing the added benefit of sanitizing the target item. This disclosure also discusses novel processes for using a treating agent to process, store, or package target items using a treating agent containing a cooling agent, such as solid carbon dioxide (“dry ice”), and a sanitizing agent, such as ozone.