A printing system includes a support arrangement. A print cartridge receiving arrangement is mounted on the support arrangement to engage a print cartridge. A drive mechanism delivers print media from the print cartridge. A print engine is mounted on the support arrangement downstream of the print cartridge and has a pair of opposed printhead assemblies that are configured to perform double-sided printing on print media fed from the print cartridge between the printhead assemblies. A slitter is mounted on the support arrangement downstream of the print engine and is configured to separate the print media into sheets.