发明申请
US20050282168A1 Cell surface molecules as markers and therapeutic agents against kidney cancers
审中-公开
细胞表面分子作为肾癌的标志物和治疗剂
- 专利标题： Cell surface molecules as markers and therapeutic agents against kidney cancers
- 专利标题（中）： 细胞表面分子作为肾癌的标志物和治疗剂
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申请号： US10671740申请日： 2003-09-29
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公开(公告)号： US20050282168A1公开(公告)日： 2005-12-22
- 发明人: Wei Liu , Maryann Whitley , Donna Slonim , Steven Howes
- 申请人： Wei Liu , Maryann Whitley , Donna Slonim , Steven Howes
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; G01N33/574 ; C12Q1/68
摘要：
Human cell surface molecules CD70 and CD203c are expressed at higher levels in kidney carcinomas, particularly renal cell carcinomas and clear cell renal cell carcinomas, yet are expressed at low levels in normal kidney and other diseased kidney tissue, and at low levels in other tissues. CD70 and CD203c show specificity towards kidney carcinomas, particularly renal cell carcinomas and clear cell renal cell carcinomas and thus can be used as diagnostic markers and therapeutic targets for these diseases. In addition, antibodies or small molecules against these molecules could be used in treatments towards these diseases.
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