The invention provides an in-vivo examination apparatus that can examine a minute examination site in a living organism with a simple configuration. The invention provides an in-vivo examination apparatus comprising a light source; a flexible light-conveying member that transmits light from the light source to irradiate the light from an end face thereof onto an examination site and that receives return light returning from the examination site at the end face thereof to transmit the return light; a long thin insertion part in which the light-conveying member is disposed along the longitudinal direction thereof; and an optical detector that detects the return light from biological tissue, which is transmitted through the insertion part via the light-conveying member. The end face of the insertion part, where the end face of the light-conveying member is exposed, is configured so as to be cut at an angle with respect to the longitudinal direction to provide a pointed portion that can incise the biological tissue at the tip thereof.