Invention Application
US20060014785A1 BICYCLIC, SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
审中-公开
作为PPAR的调节剂的双相，取代三唑类及其制备方法
- Patent Title: BICYCLIC, SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
- Patent Title (中): 作为PPAR的调节剂的双相，取代三唑类及其制备方法
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Application No.: US11137679Application Date: 2005-05-24
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Publication No.: US20060014785A1Publication Date: 2006-01-19
- Inventor: Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
- Applicant: Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
- Applicant Address: US CA Hayward
- Assignee: Metabolex, Inc.
- Current Assignee: Metabolex, Inc.
- Current Assignee Address: US CA Hayward
- Main IPC: A61K31/4709
- IPC: A61K31/4709 ; C07D403/02
Abstract:
The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
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