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    Substituted triazoles as modulators of PPAR and methods of their preparation
    1.
    发明申请
    Substituted triazoles as modulators of PPAR and methods of their preparation 有权
    取代三唑作为PPAR的调节剂及其制备方法

    公开(公告)号：US20060014809A1

    公开(公告)日：2006-01-19

    申请号：US11137678

    申请日：2005-05-24

    申请人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    发明人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    IPC分类号： A61K31/4192 ,  C07D249/04

    CPC分类号： C07D249/06 ,  C07D409/10

    摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.

    摘要翻译： 本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症 高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

    SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
    2.
    发明申请
    SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开
    取代三唑作为PPAR的调节剂及其制备方法

    公开(公告)号：US20080108630A1

    公开(公告)日：2008-05-08

    申请号：US11932755

    申请日：2007-10-31

    申请人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    发明人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    IPC分类号： A61K31/497 ,  A61P3/06 ,  A61P3/10 ,  A61K31/4192 ,  C07D403/06 ,  C07D249/04

    CPC分类号： C07D249/06 ,  C07D409/10

    摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.

    摘要翻译： 本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症 高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

    BICYCLIC, SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
    4.
    发明申请
    BICYCLIC, SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开
    作为PPAR的调节剂的双相，取代三唑类及其制备方法

    公开(公告)号：US20060014785A1

    公开(公告)日：2006-01-19

    申请号：US11137679

    申请日：2005-05-24

    申请人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    发明人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    IPC分类号： A61K31/4709 ,  C07D403/02

    CPC分类号： C07D403/12 ,  C07D403/06 ,  C07D403/14 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

    摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.

    摘要翻译： 本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症 高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

    Modulators of PPAR and methods of their preparation
    8.
    发明授权
    Modulators of PPAR and methods of their preparation 失效
    PPAR的调节剂及其制备方法

    公开(公告)号：US07622491B2

    公开(公告)日：2009-11-24

    申请号：US11202963

    申请日：2005-08-11

    申请人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine M. Gregoire ,  Vera A. Rakhmanova

    发明人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine M. Gregoire ,  Vera A. Rakhmanova

    IPC分类号： A61K31/40 ,  A61K31/415 ,  C07D207/00 ,  C07D231/00 ,  C07D233/00

    CPC分类号： C07D263/57 ,  C07D249/06 ,  C07D249/20 ,  C07D403/12 ,  C07D409/10

    摘要： The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.

    摘要翻译： 本发明涉及由式（I）表示的某些新型化合物及其药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制由PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症 高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

    Process for the stereoselective preparation of (-)-halofenate and derivatives thereof
    9.
    发明申请
    Process for the stereoselective preparation of (-)-halofenate and derivatives thereof 失效
    （ - ） - 卤代苯甲酸酯及其衍生物的立体选择性制备方法

    公开(公告)号：US20070072858A1

    公开(公告)日：2007-03-29

    申请号：US11525200

    申请日：2006-09-20

    申请人： Yan Zhu ,  Peng Cheng ,  Xin Chen ,  Jingyuan Ma ,  Zuchun Zhao

    发明人： Yan Zhu ,  Peng Cheng ,  Xin Chen ,  Jingyuan Ma ,  Zuchun Zhao

    IPC分类号： A61K31/5375 ,  A61K31/495 ,  A61K31/4025 ,  A61K31/401

    CPC分类号： C07D295/185

    摘要： The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member independently selected from the group consisting of (C1-C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4)aminoalkyl, amido, (C1-C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds

    摘要翻译： 本发明提供式（IV）化合物及其制备下式的α-（苯氧基）苯乙酸化合物的方法：其中R 1是选自以下的成员：各 R 2是独立地选自（C 1 -C 4 -C 4）烷基，卤素，（C 1 -C 4）烷基的成员， C 1 -C 4卤代烷基，氨基，（C 1 -C 4）氨基烷基，酰氨基，（C 1 H 4） （C 1 -C 4）磺酰基烷基，（C 1 -C 4）磺酰基烷基，（C 1 -C 4 - C 1 -C 4亚磺酰基烷基，（C 1 -C 4 -C 4）烷氧基，（C 1 -C 3 - 亚磺酰基烷基） > 4个）杂烷基，羧基和硝基; 当R 1具有式（a）或（b）时，下标n为1，当R 1具有式（c）或（d））时，下标n为1。 下标m为0〜3的整数; *表示富含一种立体异构构型的碳; 波浪线表示R 1的连接点; 和化合物