发明申请
US20060018904A1 Combination therapies utilizing benzamide inhibitors of the P2X7 receptor
审中-公开
使用P2X7受体的苯甲酰胺抑制剂的组合疗法
- 专利标题: Combination therapies utilizing benzamide inhibitors of the P2X7 receptor
- 专利标题(中): 使用P2X7受体的苯甲酰胺抑制剂的组合疗法
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申请号: US11168602申请日: 2005-06-28
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公开(公告)号: US20060018904A1公开(公告)日: 2006-01-26
- 发明人: James Chung , Christopher Gabel , Gail Jungbluth
- 申请人: James Chung , Christopher Gabel , Gail Jungbluth
- 专利权人: WARNER-LAMBERT COMPANY LLC
- 当前专利权人: WARNER-LAMBERT COMPANY LLC
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K31/401 ; A61K31/366 ; A61K31/165 ; A61K31/573
摘要:
This invention provides methods of treatment of IL-1 mediated diseases comprising administering a pharmaceutically effective amount of a pharmaceutical agent selected from the group of sulfasalazine, a statin, a glucocorticoid agent, an inhibitor of p38 kinase, an anti-IL-6-receptor antibody, anakinra, an IL-1 monoclonal antibody, an inhibitor of JAK3 protein tyrosine kinase, a M-CSF monoclonal antibody or a humanized anti-CD20 monoclonal antibody and a benzamide inhibitor of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The methods of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.