发明申请
- 专利标题: Compositions comprising amphotericin B, methods, and systems
- 专利标题(中): 包含两性霉素B,方法和系统的组合物
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申请号: US11158332申请日: 2005-06-21
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公开(公告)号: US20060025355A1公开(公告)日: 2006-02-02
- 发明人: Sarma Duddu , Srinivas Palakodaty , David Lechuga-Ballesteros , Danforth Miller , Alan Kugler , Christopher Frantz , Trixie Tan , Richard Malcomson , Keith Washco , Theresa Sweeney , Thomas Tarara , Sarvajna Dwivedi , Michael Eldon
- 申请人: Sarma Duddu , Srinivas Palakodaty , David Lechuga-Ballesteros , Danforth Miller , Alan Kugler , Christopher Frantz , Trixie Tan , Richard Malcomson , Keith Washco , Theresa Sweeney , Thomas Tarara , Sarvajna Dwivedi , Michael Eldon
- 申请人地址: US CA San Carlos
- 专利权人: Nektar Therapeutics
- 当前专利权人: Nektar Therapeutics
- 当前专利权人地址: US CA San Carlos
- 主分类号: A61K31/7048
- IPC分类号: A61K31/7048 ; A61K9/14 ; A61L9/04
摘要:
A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 μm to about 1.9 μm. Another composition also includes particles including at least about 95 wt % of amphotericin B, wherein at least about 80 wt % of the particles have a geometric diameter ranging from about 1.1 μm to about 1.9 μm. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 μm, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.
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