公开(公告)号：US07326691B2

公开(公告)日：2008-02-05

申请号：US11158332

申请日：2005-06-21

Applicant: Sarma Duddu ,  Srinivas Palakodaty ,  David Lechuga-Ballesteros ,  Danforth Miller ,  Alan R. Kugler ,  Christopher Frantz ,  Trixie Tan ,  Richard Malcolmson ,  Keith Washco ,  Theresa Sweeney ,  Thomas E. Tarara ,  Sarvajna Dwivedi ,  Michael A. Eldon

Inventor： Sarma Duddu ,  Srinivas Palakodaty ,  David Lechuga-Ballesteros ,  Danforth Miller ,  Alan R. Kugler ,  Christopher Frantz ,  Trixie Tan ,  Richard Malcolmson ,  Keith Washco ,  Theresa Sweeney ,  Thomas E. Tarara ,  Sarvajna Dwivedi ,  Michael A. Eldon

IPC: A61K9/14 ,  A61K31/70

CPC classification number: A61K9/0075 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1694 ,  A61K31/7048 ,  A61M15/0028 ,  A61M15/0041 ,  A61M2202/064

Abstract: A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 μm to about 1.9 μm. Another composition also includes particles including at least about 95 wt % of amphotericin B, wherein at least about 80 wt % of the particles have a geometric diameter ranging from about 1.1 μm to about 1.9 μm. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 μm, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.

Abstract translation: 组合物包括包含至少约95重量％的两性霉素B的颗粒，其中所述颗粒的质量中值直径范围为约1.1μm至约1.9μm。 另一种组合物还包括包含至少约95wt％的两性霉素B的颗粒，其中至少约80wt％的颗粒具有约1.1μm至约1.9μm的几何直径。 另一种组合物包括包括两性霉素B的颗粒，其中颗粒的质量中值直径小于约1.9μm，并且其中两性霉素B的结晶度水平至少为约20％。 单位剂量形式，递送系统和方法可以涉及类似的组合物。

公开(公告)号：US20120128728A1

公开(公告)日：2012-05-24

申请号：US12087142

申请日：2006-12-21

Applicant: Richard J. Malcolmson ,  Theresa D. Sweeney ,  Danforth P. Miller ,  Alan R. Kugler ,  Keith Washco ,  David Han ,  Ramakrishna Gadiraju ,  Farzaneh Nakhjiri

Inventor： Richard J. Malcolmson ,  Theresa D. Sweeney ,  Danforth P. Miller ,  Alan R. Kugler ,  Keith Washco ,  David Han ,  Ramakrishna Gadiraju ,  Farzaneh Nakhjiri

IPC: A61K9/14 ,  B32B5/16 ,  A61P31/10 ,  A61K31/7048 ,  C07H17/08

CPC classification number: A61K9/1611 ,  A61K9/0075 ,  A61K9/141 ,  A61K9/1617 ,  A61K31/7048 ,  Y10T428/2982

Abstract: The present invention comprises compositions and formulations comprising amphotericin B comprising less than 10% degradants, compositions and formulations comprising amphotericin B with one or more excipients, methods of making amphotericin B compositions and formulations, as well as systems for using amphotericin B compositions and formulations. Also provided are pharmaceutical compositions comprising the formulation, methods of administering the pharmaceutical compositions and methods of treating patients with the pharmaceutical compositions.

Abstract translation: 本发明包括包含两性霉素B的组合物和制剂，其包含少于10％的降解物，包含两性霉素B与一种或多种赋形剂的组合物和制剂，制备两性霉素B组合物和制剂的方法，以及使用两性霉素B组合物和制剂的系统。 还提供了药物组合物，其包含制剂，施用药物组合物的方法和用药物组合物治疗患者的方法。

公开(公告)号：US08513204B2

公开(公告)日：2013-08-20

申请号：US11523978

申请日：2006-09-20

Applicant: Richard Malcolmson ,  Alan Kugler ,  Theresa D. Sweeney ,  Keith Washco ,  Danforth Miller

Inventor： Richard Malcolmson ,  Alan Kugler ,  Theresa D. Sweeney ,  Keith Washco ,  Danforth Miller

IPC: A61K31/70

CPC classification number: A61K9/1617 ,  A61K9/0075 ,  A61K9/1611 ,  A61K9/1694 ,  A61K31/7048 ,  A61M15/0028 ,  A61M15/0041 ,  A61M2202/064

Abstract: The present invention comprises compositions and formulations comprising amphotericin B, compositions and formulations comprising amphotericin B with one or more excipients, methods of making amphotericin B compositions and formulations, as well as systems for using amphotericin B compositions and formulations. Also provided are pharmaceutical compositions comprising the formulation, methods of administering the pharmaceutical compositions and methods of treating patients with the pharmaceutical compositions.

Abstract translation: 本发明包括包含两性霉素B的组合物和制剂，包含两性霉素B与一种或多种赋形剂的组合物和制剂，制备两性霉素B组合物和制剂的方法，以及使用两性霉素B组合物和制剂的系统。 还提供了药物组合物，其包含制剂，施用药物组合物的方法和用药物组合物治疗患者的方法。

公开(公告)号：US20070123477A1

公开(公告)日：2007-05-31

申请号：US11523978

申请日：2006-09-20

Applicant: Richard Malcolmson ,  Alan Kugler ,  Theresa Sweeney ,  Keith Washco ,  Danforth Miller

Inventor： Richard Malcolmson ,  Alan Kugler ,  Theresa Sweeney ,  Keith Washco ,  Danforth Miller

IPC: A61K31/7048

CPC classification number: A61K9/1617 ,  A61K9/0075 ,  A61K9/1611 ,  A61K9/1694 ,  A61K31/7048 ,  A61M15/0028 ,  A61M15/0041 ,  A61M2202/064

Abstract: The present invention comprises compositions and formulations comprising amphotericin B, compositions and formulations comprising amphotericin B with one or more excipients, methods of making amphotericin B compositions and formulations, as well as systems for using amphotericin B compositions and formulations. Also provided are pharmaceutical compositions comprising the formulation, methods of administering the pharmaceutical compositions and methods of treating patients with the pharmaceutical compositions.

Abstract translation: 本发明包括包含两性霉素B的组合物和制剂，包含两性霉素B与一种或多种赋形剂的组合物和制剂，制备两性霉素B组合物和制剂的方法，以及使用两性霉素B组合物和制剂的系统。 还提供了药物组合物，其包含制剂，施用药物组合物的方法和用药物组合物治疗患者的方法。

公开(公告)号：US20060025355A1

公开(公告)日：2006-02-02

申请号：US11158332

申请日：2005-06-21

Applicant: Sarma Duddu ,  Srinivas Palakodaty ,  David Lechuga-Ballesteros ,  Danforth Miller ,  Alan Kugler ,  Christopher Frantz ,  Trixie Tan ,  Richard Malcomson ,  Keith Washco ,  Theresa Sweeney ,  Thomas Tarara ,  Sarvajna Dwivedi ,  Michael Eldon

Inventor： Sarma Duddu ,  Srinivas Palakodaty ,  David Lechuga-Ballesteros ,  Danforth Miller ,  Alan Kugler ,  Christopher Frantz ,  Trixie Tan ,  Richard Malcomson ,  Keith Washco ,  Theresa Sweeney ,  Thomas Tarara ,  Sarvajna Dwivedi ,  Michael Eldon

IPC: A61K31/7048 ,  A61K9/14 ,  A61L9/04

CPC classification number: A61K9/0075 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1694 ,  A61K31/7048 ,  A61M15/0028 ,  A61M15/0041 ,  A61M2202/064

Abstract: A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 μm to about 1.9 μm. Another composition also includes particles including at least about 95 wt % of amphotericin B, wherein at least about 80 wt % of the particles have a geometric diameter ranging from about 1.1 μm to about 1.9 μm. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 μm, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.

Abstract translation: 组合物包括包含至少约95重量％的两性霉素B的颗粒，其中所述颗粒的质量中值直径范围为约1.1μm至约1.9μm。 另一种组合物还包括包含至少约95wt％的两性霉素B的颗粒，其中至少约80wt％的颗粒具有约1.1μm至约1.9μm的几何直径。 另一种组合物包括包括两性霉素B的颗粒，其中颗粒的质量中值直径小于约1.9μm，并且其中两性霉素B的结晶度水平至少为约20％。 单位剂量形式，递送系统和方法可以涉及类似的组合物。

公开(公告)号：US06630168B1

公开(公告)日：2003-10-07

申请号：US08803128

申请日：1997-02-20

Applicant: Richard E. Jones ,  Keith Washco ,  Kathleen V. Roskos ,  Richard Maskiewicz ,  George Trager

Inventor： Richard E. Jones ,  Keith Washco ,  Kathleen V. Roskos ,  Richard Maskiewicz ,  George Trager

IPC: A61K910

CPC classification number: A61K9/0019 ,  A61K47/10 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38

Abstract: Methods and compositions are provided for the treatment of a host suffering from a cellular proliferative disease. In the subject methods, antiproliferative agents are administered in a substantially non-aqueous gel delivery vehicle comprising at least one polar organic solvent in combination with one or more thickening agents. The subject methods and compositions provide for the enhanced efficacy of regionally or locally administered antiproliferative proliferative agents.

Abstract translation: 提供了用于治疗患有细胞增殖性疾病的宿主的方法和组合物。 在本发明方法中，抗增殖剂在基本上非水性凝胶输送载体中施用，其包含至少一种极性有机溶剂与一种或多种增稠剂的组合。 本发明的方法和组合物提供了区域或局部施用的抗增殖性增殖剂的增强功效。