发明申请
- 专利标题: Amide derivatives and nociceptin antagonists
- 专利标题(中): 酰胺衍生物和伤害感受肽拮抗剂
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申请号: US11145169申请日: 2005-06-06
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公开(公告)号: US20060030565A1公开(公告)日: 2006-02-09
- 发明人: Hisashi Shinkai , Takao Ito , Hideki Yamada
- 申请人: Hisashi Shinkai , Takao Ito , Hideki Yamada
- 专利权人: JAPAN TOBACCO INC.
- 当前专利权人: JAPAN TOBACCO INC.
- 优先权: JP100029/1998 19980326
- 主分类号: A61K31/473
- IPC分类号: A61K31/473 ; A61K31/498 ; A61K31/47 ; A61K31/4184
摘要:
The present invention relates to a compound of the formula [1′] wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5 may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.