发明申请
- 专利标题： Amyloid-binding, metal-chelating agents
- 专利标题（中）： 淀粉样结合，金属螯合剂
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申请号： US11096919申请日： 2005-04-01
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公开(公告)号： US20060035946A1公开(公告)日： 2006-02-16
- 发明人: Xudong Huang , Jonathan Kremsky , Perry Catchings
- 申请人： Xudong Huang , Jonathan Kremsky , Perry Catchings
- 专利权人： The General Hospital Corporation,Prime Organics, Inc.
- 当前专利权人： The General Hospital Corporation,Prime Organics, Inc.
- 主分类号： A61K31/428
- IPC分类号： A61K31/428 ; C07D417/02
摘要：
The present invention relates to the diagnosis, prevention, and treatment of pathophysiological conditions associated with amyloid accumulation. Bifunctional therapeutic molecules and contrast imaging agents exhibiting a high affinity for amyloid deposits, and pharmaceutical compositions thereof are described. The invention also provides methods of using these bifunctional molecules, contrast imaging agents, and pharmaceutical compositions for detecting the presence of amyloid deposits using imaging techniques; and for preventing or treating amyloid-related conditions, such as, for example, Alzheimer's disease.