-
公开(公告)号:US20060035946A1
公开(公告)日:2006-02-16
申请号:US11096919
申请日:2005-04-01
申请人: Xudong Huang , Jonathan Kremsky , Perry Catchings
发明人: Xudong Huang , Jonathan Kremsky , Perry Catchings
IPC分类号: A61K31/428 , C07D417/02
CPC分类号: C07D277/66 , A61K31/425
摘要: The present invention relates to the diagnosis, prevention, and treatment of pathophysiological conditions associated with amyloid accumulation. Bifunctional therapeutic molecules and contrast imaging agents exhibiting a high affinity for amyloid deposits, and pharmaceutical compositions thereof are described. The invention also provides methods of using these bifunctional molecules, contrast imaging agents, and pharmaceutical compositions for detecting the presence of amyloid deposits using imaging techniques; and for preventing or treating amyloid-related conditions, such as, for example, Alzheimer's disease.
摘要翻译: 本发明涉及与淀粉样蛋白积累相关的病理生理条件的诊断,预防和治疗。 描述了对淀粉样沉积物表现出高亲和力的双功能治疗分子和造影剂,以及其药物组合物。 本发明还提供了使用成像技术使用这些双功能分子,造影剂和药物组合物来检测淀粉样沉积物的存在的方法; 并用于预防或治疗淀粉样蛋白相关病症,例如阿尔茨海默病。