发明申请
- 专利标题: Modified defensins and their use
- 专利标题(中): 改性防卫素及其用途
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申请号: US10504838申请日: 2003-02-18
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公开(公告)号: US20060036083A1公开(公告)日: 2006-02-16
- 发明人: Joel Moss , Rodney Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
- 申请人: Joel Moss , Rodney Levine , Akihiro Wada , Toshiya Hirayama , Gregorino Paone
- 国际申请: PCT/US03/04649 WO 20030218
- 主分类号: A61K38/17
- IPC分类号: A61K38/17 ; C07K14/705 ; C07H21/04 ; C12P21/06
摘要:
This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method if provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
公开/授权文献
- US07511015B2 Modified defensins and their use 公开/授权日:2009-03-31