Invention Application
US20060046985A1 Tetrahydro--4h-pyrido[1,2-a}pyrimidines and related compounds useful as hiv integrase inhibitors
有权
四氢-4H-吡啶并[1,2-a]嘧啶和有用的化合物可用作hiv整合酶抑制剂
- Patent Title: Tetrahydro--4h-pyrido[1,2-a}pyrimidines and related compounds useful as hiv integrase inhibitors
- Patent Title (中): 四氢-4H-吡啶并[1,2-a]嘧啶和有用的化合物可用作hiv整合酶抑制剂
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Application No.: US10540449Application Date: 2003-12-18
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Publication No.: US20060046985A1Publication Date: 2006-03-02
- Inventor: Benedetta Crescenzi , Olaf Kinzel , Ester Muraglia , Federica Orvieto , Giovanna Pescatore , Michael Rowley , Vincenzo Summa
- Applicant: Benedetta Crescenzi , Olaf Kinzel , Ester Muraglia , Federica Orvieto , Giovanna Pescatore , Michael Rowley , Vincenzo Summa
- Priority: US60436830 20021227; US60528776 20031212
- International Application: PCT/GB03/05536 WO 20031218
- Main IPC: A61K31/541
- IPC: A61K31/541 ; A61K31/5377 ; A61K31/519 ; C07D487/04

Abstract:
Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds of Formula (A): are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein n is an integer equal to zero, 1, 2 or 3, and R1, R3, R4, R12, R14, R16, R30, R32, R34 and R36 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Public/Granted literature
- US07414045B2 Substituted pyrimido[1,2-a]azepines useful as HIV integrase inhibitors Public/Granted day:2008-08-19
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