- 专利标题： Process for the preparation of Z-5-carboxymethylene-1,3-dioxolan-4-ones
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申请号： US11208635申请日： 2005-08-22
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公开(公告)号： US20060047129A1公开(公告)日： 2006-03-02
- 发明人: William Nugent , Keming Zhu , James Simpson , Edward Delaney
- 申请人： William Nugent , Keming Zhu , James Simpson , Edward Delaney
- 主分类号： C07D317/26
- IPC分类号： C07D317/26
摘要：
A process for preparing Z-5-carboxymethylene-1,3-dioxolan-4-ones is provided which includes the steps of reacting a bis-ketal or bis-acetal of tartaric acid with a potassium containing base to form the carboxymethylene-1,3-dioxolan-4-one. A process for preparing HIV integrase inhibitors employing the carboxymethylene-1,3-dioxolan-4-one inhibitor is also provided.
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