In various embodiments of the present invention, a noisy signal denoiser is tuned and optimized by selecting denoiser parameters that provide relatively highly compressible denoiser output. When the original signal can be compared to the output of a denoiser, the denoiser can be accurately tuned and adjusted in order to produce a denoised signal that resembles as closely as possible the clear signal originally transmitted through a noise-introducing channel. However, when the clear signal is not available, as in many communications applications, other methods are needed. By adjusting the parameters to provide a denoised signal that is globally or locally maximally compressible, the denoiser can be optimized despite inaccessibility of the original, clear signal.