发明申请
- 专利标题： Cyclopamine analogues and methods of use thereof
- 专利标题（中）： 环戊胺类似物及其使用方法
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申请号： US11213534申请日： 2005-08-26
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公开(公告)号： US20060074030A1公开(公告)日： 2006-04-06
- 发明人: Julian Adams , Alfredo Castro , Michael Foley , Somarajan Janardanan Nair , Marta Nevalainen , James Porter , Martin Tremblay
- 申请人： Julian Adams , Alfredo Castro , Michael Foley , Somarajan Janardanan Nair , Marta Nevalainen , James Porter , Martin Tremblay
- 主分类号： A61K31/7052
- IPC分类号： A61K31/7052 ; A61K31/4747 ; C07D491/10
摘要：
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
公开/授权文献
- US07230004B2 Cyclopamine analogues and methods of use thereof 公开/授权日：2007-06-12
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