Abstract:
A method comprising syncing, by a platform implemented by one or more processors, a plurality of computer files within an existing client data repository on a server to a specified geolocated polygons on a digital mapping interface, wherein the plurality of computer files are at least one of standalone computer files or computer files in a plurality of file directories; utilizing, by the platform, a geolocated polygon and attribute recommendation tool such that multiple embedded engines including (i) file directory and computer file property parsing to generate address or building name query strings to be processed through a machine learning gazetteer system; and (ii) optical character recognition to locate the address or building name query strings, to be processed through the machine learning gazetteer system, and keywords, processed into n-gram data structures to be cross-referenced against multiple internal or external keyword databases; and recommending, by the platform, geolocated polygons and geofile attributes, wherein all synced computer files are reviewed by a user and released to a geofile publication engine to be converted into a geofile and displayed on the digital mapping interface.
Abstract:
A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.
Abstract:
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
Abstract:
An integral biomolecule preparation device which accomplishes all of the nucleic acid separation steps, including centrifugation, reagent addition, and pipeting, automatically without human intervention to fully automate the DNA separation procedure.
Abstract:
The present invention is directed to a conveyor belt cleaning apparatus comprising a frame having a front side, a rear side, two lateral sides and one or more openings located between the front side, the rear side and the lateral sides; a first scraping blade and a second scraping blade, wherein each of the scraping blades is positioned between the lateral sides of the frame, and wherein the second scraping blade is rearward of the first scraping blade; and means for securing the frame to the underside of a conveyor belt assembly such that the first scraping blade and the second scraping blade make contact with the conveyor belt of the conveyor belt assembly.
Abstract:
A method performed by a computing device and having one or more processors and memory storing one or more programs for execution by the one or more processors, comprising information including a representation of at least one compliance issue is received. The information is analyzed to determine at least one entity to which the at least one compliance issue is pertinent. The information is forwarded to the at least one entity in response to a determination that the legal change is pertinent to the at least one entity. A response is received from the at least one entity a response including a representation as to how the at least one entity intends to address the compliance issue.
Abstract:
The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
Abstract:
The invention features a method of screening two-entity or higher order combinations for biological activity using combinational arrays. The method includes the steps of: (a) providing the entities, (b) creating an array of combinations of entities, (c) providing a test element that includes one or more distinct biological moieties, (d) contacting the array of combinations of entities with the test element under conditions that ensure that each entity/test element contacting is segregated from the others, (e) detecting or measuring a property of the test element, and (f) identifying combinations of entities that cause an effect on the property of the test element that is different from the effect of an entity of the combination by itself.