发明申请
US20060074041A1 Antisense and antigene therapeutics with improved binding properties and methods for their use
审中-公开
具有改进的结合性质的反义和抗原治疗剂及其使用方法
- 专利标题： Antisense and antigene therapeutics with improved binding properties and methods for their use
- 专利标题（中）： 具有改进的结合性质的反义和抗原治疗剂及其使用方法
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申请号： US11228705申请日： 2005-09-16
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公开(公告)号： US20060074041A1公开(公告)日： 2006-04-06
- 发明人: Brian Johnston , Sergei Kazakov , Kevin Kisich
- 申请人： Brian Johnston , Sergei Kazakov , Kevin Kisich
- 申请人地址： US CA Santa Cruz
- 专利权人： Somagenics, Inc.
- 当前专利权人： Somagenics, Inc.
- 当前专利权人地址： US CA Santa Cruz
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/02
摘要：
The present invention is directed to novel nucleic acid molecules and methods for their use. More specifically, the novel nucleic acid molecules of the present invention are capable of tightly and specifically interacting with a target molecule of interest not only through standard Watson-Crick base pairing, but also through additional features which allow the antisense molecules to become topologically “locked” onto the target nucleic acid, thereby imparting improved transcription and translation inhibitory properties.
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