A door latch system of a motor vehicle comprises a latch unit mounted to the vehicle body. The latch unit has a latch condition to latch the door at a closed position and an unlatch condition to unlatch the door thereby to release the door. The system further comprises a power latch canceling mechanism mounted to the vehicle body. The power latch canceling mechanism includes an actuator that, when energized, enforcedly causes the latch unit to assume the unlatch condition. The system further comprises a manual latch canceling mechanism mounted to the vehicle body. The manual latch canceling mechanism includes a handle member that is placed at a position other than a vehicle cabin of the vehicle and a power transmitting member that transmits a movement of the handle member to the latch unit. The manual latch canceling mechanism causes the latch unit to assume the unlatch condition when the handle member is manipulated.