Invention Application
- Patent Title: Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof
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Application No.: US11209998Application Date: 2005-08-22
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Publication No.: US20060084647A1Publication Date: 2006-04-20
- Inventor: Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
- Applicant: Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
- Applicant Address: US MI Ann Arbor
- Assignee: Regents of the University of Michigan
- Current Assignee: Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/506 ; A61K31/4709 ; A61K31/47 ; A61K31/445 ; A61K31/165 ; C07D413/02 ; C07D401/02 ; C07C317/32
Abstract:
The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
Public/Granted literature
- US08557812B2 Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof Public/Granted day:2013-10-15
Information query
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