发明申请
- 专利标题： Heterocyclic compounds and thrombopoietin receptor activators
- 专利标题（中）： 杂环化合物和血小板生成素受体激活剂
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申请号： US11294609申请日： 2005-12-06
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公开(公告)号： US20060094694A1公开(公告)日： 2006-05-04
- 发明人: Shingo Owada , Shunsuke Iwamoto , Kazufumi Yanagihara , Katsuaki Miyaji , Takanori Nakamura , Norihisa Ishiwata , Yutaka Hirokawa
- 申请人： Shingo Owada , Shunsuke Iwamoto , Kazufumi Yanagihara , Katsuaki Miyaji , Takanori Nakamura , Norihisa Ishiwata , Yutaka Hirokawa
- 申请人地址： JP Tokyo
- 专利权人： Nissan Chemical Industries Limited
- 当前专利权人： Nissan Chemical Industries Limited
- 当前专利权人地址： JP Tokyo
- 优先权： JP2003-161987 20030606; JP2003-330627 20030922; JP2003-404635 20031203; JP2004-094931 20040329
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; C07D261/12 ; C07D231/08 ; A61K31/42 ; A61K31/4152
摘要：
A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14 aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13 SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.