发明申请
- 专利标题: Mass scale alignment of time-of-flight mass spectra
- 专利标题(中): 飞行时间质谱的质谱比对
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申请号: US11249147申请日: 2005-10-12
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公开(公告)号: US20060095212A1公开(公告)日: 2006-05-04
- 发明人: Markus Kostrzewa , Stefan Klepel , Thomas Maier
- 申请人: Markus Kostrzewa , Stefan Klepel , Thomas Maier
- 申请人地址: DE Bremen
- 专利权人: Bruker Daltonik GmbH
- 当前专利权人: Bruker Daltonik GmbH
- 当前专利权人地址: DE Bremen
- 优先权: DE102004051043.1 20041020
- 主分类号: G06F19/00
- IPC分类号: G06F19/00
摘要:
The invention generates mass scale comparability between mass spectra which are acquired in time-of-flight mass spectrometers, particularly with ionization by matrix-assisted laser desorption. Always slightly distorted mass scales of different mass spectra from the same type of sample can be aligned. The flight times of identical ions always differ slightly from one mass spectrum to the next due to non-reproducible processes in the ionization method. Thus the apparent mass values of ion signals of identical substances in different mass spectra do not match even if the flight times are converted into mass values with the identical calibration equation. After alignment of the mass scales, mass spectra can be reliably compared with respect to deviations in intensities of bio-makers, or be added together without deterioration in the mass resolution, and improved reference spectrum libraries can be created. Furthermore, the invention allows more reliable library searches to be carried out.
公开/授权文献
- US07391017B2 Mass scale alignment of time-of-flight mass spectra 公开/授权日:2008-06-24