发明申请
- 专利标题: Abuse-resistant pharmaceutical compositions
- 专利标题(中): 滥用药物组合物
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申请号: US10528727申请日: 2003-09-23
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公开(公告)号: US20060104909A1公开(公告)日: 2006-05-18
- 发明人: Farid Vaghefi , Gary Liversidge , Stephen Ruddy , Eugene Cooper
- 申请人: Farid Vaghefi , Gary Liversidge , Stephen Ruddy , Eugene Cooper
- 国际申请: PCT/US03/29890 WO 20030923
- 主分类号: A61K9/44
- IPC分类号: A61K9/44
摘要:
An abuse-resistant controlled release pharmaceutical composition comprising a pharmaceutically effective amount of discrete particles of an active capable of abuse, wherein surfaces of said particles are wetted with a water insoluble coating material, and preferably wherein said composition comprises a matrix, in which said particles are distributed, and which renders the abuse-capable compound within the matrix difficult to separate from the matrix; and a method for the preparation of a controlled release pharmaceutical composition having a reduced potential for abuse, comprising applying a pressure force to a mixture comprising a water insoluble material, and particles of a pharmaceutically active compound capable of inducing in a subject a reaction that is physiologically or psychologically detrimental if administered in an immediate release dosage form, thereby resulting in surface coated particles, and incorporating said surface coated particles into a pharmaceutical composition
公开/授权文献
- US08623412B2 Abuse-resistant pharmaceutical compositions 公开/授权日:2014-01-07
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